Bislol
Generic Name
Bisoprolol Fumarate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bislol 75 mg tablet | ৳ 16.00 | ৳ 224.00 |
Description
Overview of the medicine
Bislol 7.5 mg Tablet contains Bisoprolol Fumarate, a beta-blocker used to treat high blood pressure, angina, and chronic stable heart failure. It works by slowing down the heart rate and relaxing blood vessels.
Uses & Indications
Dosage
Adults
Hypertension/Angina: Initially 5 mg once daily, may be increased to 10 mg once daily. Max 20 mg once daily. Heart Failure: Initially 1.25 mg once daily, titrate up slowly over weeks to a maximum of 10 mg once daily, as tolerated.
Elderly
No specific dose adjustment is usually required unless there is significant renal or hepatic impairment. Start with lower doses and titrate carefully.
Renal_impairment
For severe renal impairment (creatinine clearance < 20 mL/min), or severe hepatic impairment, do not exceed 10 mg once daily. Start with 2.5 mg or 5 mg once daily.
How to Take
Take the tablet orally once daily in the morning, with or without food. Swallow whole with water, do not chew or crush. Do not stop taking it suddenly.
Mechanism of Action
Bisoprolol is a highly beta-1 selective adrenergic receptor blocker. It selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, myocardial contractility, and cardiac output, leading to decreased blood pressure. It also reduces renin release from the kidneys.
Pharmacokinetics
Onset
Within 2-4 hours for peak effect.
Excretion
Approximately 50% renally excreted unchanged; the remaining 50% is excreted as inactive metabolites.
Half life
Approximately 10-12 hours.
Absorption
Well absorbed from the GI tract (over 90% bioavailability), unaffected by food.
Metabolism
Approximately 50% metabolized by the liver (CYP2D6).
Side Effects
Contraindications
- Acute heart failure or during episodes of decompensated heart failure requiring intravenous inotropic therapy
- Cardiogenic shock
- Second or third degree AV block (without a pacemaker)
- Sick sinus syndrome (without a pacemaker)
- Severe bradycardia (heart rate < 60 bpm before treatment)
- Severe asthma or severe chronic obstructive pulmonary disease (COPD)
- Severe peripheral arterial occlusive disease or Raynaud's syndrome
- Phaeochromocytoma (untreated)
- Metabolic acidosis
- Hypersensitivity to bisoprolol or any components of the tablet
Drug Interactions
NSAIDs (e.g., ibuprofen)
May reduce the hypotensive effect of bisoprolol.
Antiarrhythmics (e.g., disopyramide, amiodarone)
Increased risk of cardiac depression and bradycardia.
Calcium channel blockers (e.g., verapamil, diltiazem)
Increased risk of bradycardia, hypotension, and heart failure.
Tricyclic antidepressants, barbiturates, phenothiazines
Increased risk of hypotension.
Other antihypertensives (e.g., ACE inhibitors, diuretics)
Potentiated hypotensive effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include bradycardia, hypotension, bronchospasm, and acute cardiac insufficiency. Management involves symptomatic and supportive treatment; gastric lavage, activated charcoal, IV fluids, atropine for bradycardia, glucagon, or other interventions as needed.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Bisoprolol is excreted in breast milk; caution should be exercised when administered to a nursing mother. Consult a doctor.
Side Effects
Contraindications
- Acute heart failure or during episodes of decompensated heart failure requiring intravenous inotropic therapy
- Cardiogenic shock
- Second or third degree AV block (without a pacemaker)
- Sick sinus syndrome (without a pacemaker)
- Severe bradycardia (heart rate < 60 bpm before treatment)
- Severe asthma or severe chronic obstructive pulmonary disease (COPD)
- Severe peripheral arterial occlusive disease or Raynaud's syndrome
- Phaeochromocytoma (untreated)
- Metabolic acidosis
- Hypersensitivity to bisoprolol or any components of the tablet
Drug Interactions
NSAIDs (e.g., ibuprofen)
May reduce the hypotensive effect of bisoprolol.
Antiarrhythmics (e.g., disopyramide, amiodarone)
Increased risk of cardiac depression and bradycardia.
Calcium channel blockers (e.g., verapamil, diltiazem)
Increased risk of bradycardia, hypotension, and heart failure.
Tricyclic antidepressants, barbiturates, phenothiazines
Increased risk of hypotension.
Other antihypertensives (e.g., ACE inhibitors, diuretics)
Potentiated hypotensive effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include bradycardia, hypotension, bronchospasm, and acute cardiac insufficiency. Management involves symptomatic and supportive treatment; gastric lavage, activated charcoal, IV fluids, atropine for bradycardia, glucagon, or other interventions as needed.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Bisoprolol is excreted in breast milk; caution should be exercised when administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 36 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials (e.g., CIBIS, US Carvedilol Heart Failure Studies) have demonstrated the efficacy and safety of bisoprolol in hypertension, angina, and chronic heart failure.
Lab Monitoring
- Blood pressure monitoring
- Heart rate monitoring
- Renal function (creatinine, BUN) periodically
- Liver function tests periodically (if hepatic impairment suspected)
Doctor Notes
- Carefully monitor patients for signs of heart failure exacerbation, especially during dose titration.
- Counsel patients on the importance of gradual discontinuation to avoid rebound adrenergic effects.
- Consider alternative agents or caution in patients with severe asthma/COPD or peripheral arterial disease.
Patient Guidelines
- Do not stop taking Bisoprolol suddenly, as it may worsen your condition. Consult your doctor.
- Take your medicine at the same time each day to help you remember.
- Inform your doctor or dentist that you are taking Bisoprolol before any surgery or dental procedure.
- Monitor your blood pressure and heart rate regularly as advised by your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Bisoprolol may cause dizziness or fatigue, especially at the start of treatment or when the dose is changed. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Adopt a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as recommended by your doctor.
- Maintain a healthy weight.
- Avoid smoking and limit alcohol consumption.
- Manage stress through relaxation techniques.
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