Bisoloc
Generic Name
Bisoprolol Fumarate
Manufacturer
Square Pharmaceuticals PLC.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bisoloc 5 mg tablet | ৳ 11.00 | ৳ 110.00 |
Description
Overview of the medicine
Bisoloc 5 mg tablet contains Bisoprolol Fumarate, a beta-1 selective adrenergic blocker, used for the management of hypertension, angina pectoris, and chronic heart failure.
Uses & Indications
Dosage
Adults
Hypertension/Angina: Initially 5 mg once daily, may be increased to 10 mg once daily. Max 20 mg/day. Heart failure: Initially 1.25 mg once daily, gradually titrate up to 10 mg once daily over several weeks.
Elderly
No dose adjustment generally required unless severe renal or hepatic impairment. Start with lowest dose.
Renal_impairment
CrCl < 20 mL/min: Max 10 mg/day. Dialysis: No additional dose required.
How to Take
Oral administration, usually taken once daily in the morning with or without food. Tablets should be swallowed whole with some liquid, not chewed or crushed.
Mechanism of Action
Bisoprolol selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, cardiac output, and blood pressure. It also reduces renin release from the kidneys.
Pharmacokinetics
Onset
1-2 hours
Excretion
Approximately 50% excreted unchanged via kidneys, 50% as metabolites.
Half life
9-12 hours
Absorption
Well absorbed orally, bioavailability about 80%.
Metabolism
Approximately 50% metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Acute heart failure or during episodes of decompensated heart failure requiring intravenous inotropic therapy
- Cardiogenic shock
- Second or third degree AV block (without a pacemaker)
- Sick sinus syndrome
- Sinoatrial block
- Bradycardia (<60 bpm) before start of treatment
- Hypotension (systolic blood pressure <100 mmHg)
- Severe bronchial asthma or severe chronic obstructive pulmonary disease (COPD)
- Severe forms of peripheral arterial occlusive disease or Raynaud's syndrome
- Untreated phaeochromocytoma
- Metabolic acidosis
- Hypersensitivity to bisoprolol or any excipients
Drug Interactions
NSAIDs
May reduce the hypotensive effects of bisoprolol.
Clonidine
Exacerbation of rebound hypertension upon withdrawal of clonidine.
Antiarrhythmics (e.g., disopyramide, amiodarone)
Potentiation of cardiodepressant effects.
Calcium channel blockers (e.g., verapamil, diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include bradycardia, hypotension, bronchospasm, acute cardiac insufficiency. Treatment is symptomatic and supportive (e.g., atropine for bradycardia, IV fluids for hypotension, bronchodilators for bronchospasm).
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Avoid during lactation as bisoprolol is excreted in breast milk.
Side Effects
Contraindications
- Acute heart failure or during episodes of decompensated heart failure requiring intravenous inotropic therapy
- Cardiogenic shock
- Second or third degree AV block (without a pacemaker)
- Sick sinus syndrome
- Sinoatrial block
- Bradycardia (<60 bpm) before start of treatment
- Hypotension (systolic blood pressure <100 mmHg)
- Severe bronchial asthma or severe chronic obstructive pulmonary disease (COPD)
- Severe forms of peripheral arterial occlusive disease or Raynaud's syndrome
- Untreated phaeochromocytoma
- Metabolic acidosis
- Hypersensitivity to bisoprolol or any excipients
Drug Interactions
NSAIDs
May reduce the hypotensive effects of bisoprolol.
Clonidine
Exacerbation of rebound hypertension upon withdrawal of clonidine.
Antiarrhythmics (e.g., disopyramide, amiodarone)
Potentiation of cardiodepressant effects.
Calcium channel blockers (e.g., verapamil, diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include bradycardia, hypotension, bronchospasm, acute cardiac insufficiency. Treatment is symptomatic and supportive (e.g., atropine for bradycardia, IV fluids for hypotension, bronchodilators for bronchospasm).
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Avoid during lactation as bisoprolol is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for hypertension, angina, and chronic heart failure, demonstrating efficacy and safety.
Lab Monitoring
- Blood pressure
- Heart rate
- Renal function (especially in elderly or with pre-existing impairment)
- Liver function (rarely)
Doctor Notes
- Counsel patients on gradual withdrawal.
- Monitor heart rate and blood pressure regularly.
- Caution in patients with obstructive airway disease or diabetes.
Patient Guidelines
- Do not stop taking bisoprolol abruptly without consulting your doctor.
- Take your medicine at the same time each day.
- Report any unusual symptoms like slow heart rate, dizziness, or shortness of breath to your doctor.
- Avoid excessive alcohol consumption.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or fatigue, especially at the start of treatment or when the dose is changed. Patients should be warned not to drive or operate machinery if they experience these symptoms.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Manage stress effectively.
- Quit smoking if applicable.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Bisoloc Brand
Other medicines available under the same brand name
