Bisoren

Administer orally once daily in the morning with or without food. Swallow the tablet whole with some liquid, do not chew or crush.

Bisoprolol is a highly selective beta-1 adrenergic receptor blocker. It reduces heart rate, myocardial contractility, and cardiac output, leading to a reduction in blood pressure. It also decreases renin release from the kidneys. Its cardioselectivity is relative and decreases with increasing doses.

• Acute heart failure or during episodes of decompensated heart failure requiring intravenous inotropic therapy
• Cardiogenic shock
• Sick sinus syndrome (unless a pacemaker is in situ)
• Second- or third-degree AV block (without a pacemaker)
• Severe bradycardia (heart rate <60 beats/min before treatment)
• Severe hypotension
• Severe bronchial asthma or severe chronic obstructive pulmonary disease (COPD)
• Severe forms of peripheral arterial occlusive disease or Raynaud's syndrome
• Metabolic acidosis
• Phaeochromocytoma (unless pre-treated with alpha-blockers)

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms of overdose include bradycardia, hypotension, bronchospasm, acute cardiac insufficiency, and hypoglycemia. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered. Atropine for severe bradycardia, glucagon for hypotension/heart failure, beta-2 sympathomimetics for bronchospasm, and intravenous glucose for hypoglycemia.

Pregnancy: Bisoprolol should only be used during pregnancy if the potential benefit outweighs the potential risk to the fetus. It can cause fetal growth retardation, bradycardia, and hypoglycemia. Lactation: Small amounts of bisoprolol are excreted in human milk. Breastfeeding is generally not recommended during bisoprolol treatment.

• Acute heart failure or during episodes of decompensated heart failure requiring intravenous inotropic therapy
• Cardiogenic shock
• Sick sinus syndrome (unless a pacemaker is in situ)
• Second- or third-degree AV block (without a pacemaker)
• Severe bradycardia (heart rate <60 beats/min before treatment)
• Severe hypotension
• Severe bronchial asthma or severe chronic obstructive pulmonary disease (COPD)
• Severe forms of peripheral arterial occlusive disease or Raynaud's syndrome
• Metabolic acidosis
• Phaeochromocytoma (unless pre-treated with alpha-blockers)

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms of overdose include bradycardia, hypotension, bronchospasm, acute cardiac insufficiency, and hypoglycemia. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered. Atropine for severe bradycardia, glucagon for hypotension/heart failure, beta-2 sympathomimetics for bronchospasm, and intravenous glucose for hypoglycemia.

Pregnancy: Bisoprolol should only be used during pregnancy if the potential benefit outweighs the potential risk to the fetus. It can cause fetal growth retardation, bradycardia, and hypoglycemia. Lactation: Small amounts of bisoprolol are excreted in human milk. Breastfeeding is generally not recommended during bisoprolol treatment.