Bivara
Generic Name
Bivaracine
Manufacturer
GlobalPharma Inc.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bivara 50 mg oral solution | ৳ 800.00 | N/A |
Description
Overview of the medicine
Bivara 50 mg Oral Solution is an antiviral medication used to treat specific viral infections. It works by inhibiting the replication of viruses in the body, helping to reduce viral load and manage symptoms. It is formulated as an oral solution for easy administration, especially in patients who may have difficulty swallowing tablets.
Uses & Indications
Dosage
Adults
50 mg (5 ml) orally twice daily, with or without food. Duration of treatment depends on the specific viral infection and patient response.
Elderly
No specific dose adjustment is required for elderly patients, but renal function should be monitored.
Renal_impairment
For patients with moderate to severe renal impairment (CrCl < 50 mL/min), the dose should be reduced to 25 mg (2.5 ml) once daily or as per physician's advice based on creatinine clearance.
How to Take
Take the prescribed dose orally using the provided measuring spoon or syringe. It can be taken with or without food. Do not dilute the solution unless instructed by a healthcare professional.
Mechanism of Action
Bivaracine is a direct-acting antiviral agent that selectively inhibits viral DNA polymerase, an enzyme essential for viral replication. By interfering with this process, Bivaracine prevents the virus from multiplying, thereby reducing the viral burden in infected cells and tissues.
Pharmacokinetics
Onset
Antiviral effects typically observed within 24-48 hours of initiation of therapy.
Excretion
Excreted predominantly by the kidneys (approximately 70% as unchanged drug and metabolites) and a minor portion through bile/feces.
Half life
Elimination half-life is approximately 6-8 hours, supporting twice-daily dosing.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours. Bioavailability is approximately 80%.
Metabolism
Primarily metabolized in the liver via CYP3A4, with some active metabolites formed.
Side Effects
Contraindications
- Hypersensitivity to Bivaracine or any component of the oral solution.
- Severe hepatic impairment.
Drug Interactions
Acyclovir
May increase plasma concentration of Bivaracine. Monitor for adverse effects.
Ritonavir
Potent CYP3A4 inhibitor, may significantly increase Bivaracine levels. Dose adjustment of Bivaracine may be necessary.
Didanosine
Increased risk of pancreatitis and lactic acidosis when co-administered. Avoid co-administration.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, supportive measures should be implemented immediately. There is no specific antidote for Bivaracine. Hemodialysis may be effective in removing Bivaracine from the circulation.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Bivaracine is excreted in human milk; caution should be exercised when administered to a nursing mother. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Bivaracine or any component of the oral solution.
- Severe hepatic impairment.
Drug Interactions
Acyclovir
May increase plasma concentration of Bivaracine. Monitor for adverse effects.
Ritonavir
Potent CYP3A4 inhibitor, may significantly increase Bivaracine levels. Dose adjustment of Bivaracine may be necessary.
Didanosine
Increased risk of pancreatitis and lactic acidosis when co-administered. Avoid co-administration.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, supportive measures should be implemented immediately. There is no specific antidote for Bivaracine. Hemodialysis may be effective in removing Bivaracine from the circulation.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Bivaracine is excreted in human milk; caution should be exercised when administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored correctly.
Availability
Pharmacies nationwide
Approval Status
Approved by national regulatory authority
Patent Status
Patented
Clinical Trials
Clinical trials (Phase II and Phase III) demonstrated significant reduction in viral load and improvement in clinical outcomes in patients with targeted viral infections compared to placebo.
Lab Monitoring
- Renal function (creatinine clearance, serum creatinine) at baseline and periodically during treatment.
- Liver function tests (ALT, AST, bilirubin) at baseline and periodically.
- Viral load measurements to assess treatment efficacy.
Doctor Notes
- Emphasize adherence to the prescribed regimen for optimal efficacy and to prevent resistance.
- Monitor renal function, liver enzymes, and viral load regularly.
- Counsel patients on potential drug interactions and side effects.
Patient Guidelines
- Do not stop taking Bivara without consulting your doctor, even if you feel better.
- Take the medicine exactly as prescribed by your doctor.
- Inform your doctor about all other medications, supplements, or herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Bivara may cause dizziness in some patients. If you experience dizziness or visual disturbances, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol consumption as it may worsen liver side effects.
- Practice safe sex to prevent transmission of viral infections.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Bivara Brand
Other medicines available under the same brand name
