Blextin
Generic Name
Bilastine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| blextin 10 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Blextin 10 mg tablet contains Bilastine, a non-sedating antihistamine used to relieve symptoms of allergic rhinoconjunctivitis (seasonal and perennial) and urticaria (hives). It is primarily indicated for use in children aged 6 to 11 years.
Uses & Indications
Dosage
Adults
The standard adult dose for Bilastine is 20 mg once daily. For children aged 12 years and above, 20 mg once daily. For the 10 mg tablet, adult use is typically not the standard therapeutic dose unless directed by a physician for specific circumstances or if two 10 mg tablets are prescribed to achieve the 20 mg dose.
Elderly
No dose adjustment is generally required for elderly patients. Experience in patients over 65 years is limited.
Children
10 mg once daily for children aged 6 to 11 years (with a body weight of at least 20 kg). The tablet should be swallowed with water.
Renal_impairment
No dose adjustment is generally required for adults and adolescents with renal impairment. For children with renal impairment, consult a pediatrician.
How to Take
Take the tablet orally once daily. It should be taken on an empty stomach, either one hour before or two hours after food or fruit juice (especially grapefruit juice), as food reduces the bioavailability of bilastine.
Mechanism of Action
Bilastine acts as a selective peripheral H1-receptor antagonist, blocking the effects of histamine and thereby reducing allergic symptoms such as sneezing, runny nose, itchy eyes, and skin rashes.
Pharmacokinetics
Onset
Onset of action typically occurs within 30-60 minutes.
Excretion
Approximately 95% of the dose is excreted unchanged, with about 67% via feces and 28% via urine. Renal and hepatic impairment do not significantly affect elimination.
Half life
Mean elimination half-life is approximately 14.5 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentration (Tmax) is reached in approximately 1.3 hours. Absolute oral bioavailability is about 61%. Food (especially grapefruit juice) significantly reduces bioavailability.
Metabolism
Bilastine is not significantly metabolized in humans. It is not an inducer or inhibitor of CYP450 isoenzymes.
Side Effects
Contraindications
- Hypersensitivity to bilastine or any of the excipients of the tablet.
Drug Interactions
Diltiazem
Increases plasma levels of bilastine (due to P-gp inhibition).
Ritonavir
Possible increase in bilastine exposure.
Cyclosporine
Possible increase in bilastine exposure.
Erythromycin
Increases plasma levels of bilastine (due to P-gp inhibition).
Ketoconazole
Increases plasma levels of bilastine (due to P-gp inhibition).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment is recommended. There is no specific antidote for bilastine. Gastric lavage and activated charcoal may be considered if ingestion was recent. Monitor vital signs and clinical status.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harmful effects on pregnancy or fetal development. However, data from pregnant women are limited. Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk. It is unknown whether bilastine is excreted in human breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to bilastine or any of the excipients of the tablet.
Drug Interactions
Diltiazem
Increases plasma levels of bilastine (due to P-gp inhibition).
Ritonavir
Possible increase in bilastine exposure.
Cyclosporine
Possible increase in bilastine exposure.
Erythromycin
Increases plasma levels of bilastine (due to P-gp inhibition).
Ketoconazole
Increases plasma levels of bilastine (due to P-gp inhibition).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment is recommended. There is no specific antidote for bilastine. Gastric lavage and activated charcoal may be considered if ingestion was recent. Monitor vital signs and clinical status.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harmful effects on pregnancy or fetal development. However, data from pregnant women are limited. Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk. It is unknown whether bilastine is excreted in human breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, refer to the product packaging for specific details.
Availability
Available in pharmacies
Approval Status
Approved in many countries (e.g., EU, Canada, Bangladesh)
Patent Status
Varies by region and formulation; original patent expired in some regions
Clinical Trials
Bilastine has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of allergic rhinoconjunctivitis and urticaria in both adults and children. Ongoing post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Routine laboratory monitoring is generally not required for bilastine. Liver and kidney function tests may be considered in patients with pre-existing impairment.
Doctor Notes
- Emphasize the importance of taking bilastine on an empty stomach to optimize absorption.
- Advise patients that while generally non-sedating, individual responses may vary.
- For pediatric patients (6-11 years) ensure parents/guardians understand the correct 10 mg once daily dosage.
Patient Guidelines
- Take Blextin 10 mg exactly as prescribed by your doctor, usually once daily.
- Take it on an empty stomach, either 1 hour before or 2 hours after food or fruit juice.
- Do not exceed the recommended dose.
- If drowsiness occurs, avoid activities requiring mental alertness like driving or operating machinery.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Although bilastine is generally non-sedating, some individuals may experience drowsiness. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Identify and try to avoid triggers for your allergies (e.g., pollen, dust mites, pet dander).
- Maintain good indoor air quality.
- Stay hydrated.
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