BNZ
Generic Name
Benzafenac 1% w/v Suspension
Manufacturer
PharmaCo Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bnz 1 suspension | ৳ 500.00 | N/A |
Description
Overview of the medicine
BNZ 1% Suspension is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and fever. It is typically prescribed for conditions such as arthritis, musculoskeletal pain, and dysmenorrhea.
Uses & Indications
Dosage
Adults
Initially 10 ml (100 mg) three times daily, adjusted according to response and tolerability. Max 30 ml (300 mg) daily.
Elderly
Lower doses may be required, generally 5 ml (50 mg) two to three times daily, with careful monitoring.
Renal_impairment
Reduced dosage is recommended. For mild to moderate impairment, 5 ml (50 mg) twice daily; severe impairment is contraindicated.
How to Take
Shake the bottle well before use. Take the medicine orally, preferably with or after food, to minimize gastrointestinal upset. Use the provided measuring cup or spoon for accurate dosing.
Mechanism of Action
Benzafenac, the active ingredient, works by inhibiting the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes are responsible for the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. By reducing prostaglandin production, Benzafenac effectively alleviates these symptoms.
Pharmacokinetics
Onset
30-60 minutes for analgesic effect.
Excretion
Mainly excreted via urine (60-70%) and feces (30-40%) as metabolites and a small amount of unchanged drug.
Half life
Approximately 2-4 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver by oxidation and conjugation.
Side Effects
Contraindications
- Hypersensitivity to Benzafenac or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, drowsiness, and rarely, gastrointestinal bleeding, acute renal failure, or respiratory depression. Management is primarily supportive; gastric lavage or activated charcoal may be considered if ingestion is recent. Monitor vital signs and renal function.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm. Use during early pregnancy or lactation only if clearly needed and the potential benefit outweighs the risk. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Benzafenac or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, drowsiness, and rarely, gastrointestinal bleeding, acute renal failure, or respiratory depression. Management is primarily supportive; gastric lavage or activated charcoal may be considered if ingestion is recent. Monitor vital signs and renal function.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm. Use during early pregnancy or lactation only if clearly needed and the potential benefit outweighs the risk. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Clinical trials have demonstrated the efficacy and safety of Benzafenac in various pain and inflammatory conditions. Ongoing studies continue to explore its long-term effects and potential new indications.
Lab Monitoring
- Complete blood count (CBC) for prolonged use
- Renal function (BUN, creatinine) periodically
- Liver function tests (ALT, AST) periodically
Doctor Notes
- Always assess patient's cardiovascular and gastrointestinal risk factors before prescribing NSAIDs.
- Monitor renal function, especially in elderly or patients with pre-existing renal impairment.
- Advise patients on the lowest effective dose for the shortest possible duration.
Patient Guidelines
- Always take this medicine exactly as your doctor has told you.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any unusual bleeding or persistent stomach upset immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or drowsiness in some individuals. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Avoid smoking and excessive alcohol consumption to reduce the risk of gastrointestinal issues.
- Maintain a healthy and balanced diet.
- Consult your doctor before taking any over-the-counter pain relievers.
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Global Brand Names
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