Bomaz
Generic Name
Bromazepam
Manufacturer
Medix Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bomaz 3 mg tablet | ৳ 4.01 | ৳ 40.10 |
Description
Overview of the medicine
Bomaz 3 mg Tablet contains Bromazepam, a benzodiazepine used for the short-term treatment of anxiety, panic attacks, and sleep disturbances associated with anxiety.
Uses & Indications
Dosage
Adults
Anxiety: 3-6 mg two to three times daily. Insomnia: 6-12 mg at bedtime. Max 30 mg/day.
Elderly
Initially 1.5 mg two to three times daily. Max 12 mg/day. Dosage should be reduced due to increased sensitivity.
Renal_impairment
Dosage reduction may be necessary. Start with lower doses and monitor response carefully.
How to Take
Take orally with or without food. Do not stop abruptly.
Mechanism of Action
Bromazepam enhances the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, at the GABA-A receptors in the brain. This results in anxiolytic, sedative, muscle relaxant, and anticonvulsant effects.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly excreted in urine as metabolites.
Half life
Approximately 10-20 hours.
Absorption
Well absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4, into inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to bromazepam or other benzodiazepines.
- Severe respiratory insufficiency (e.g., severe COPD, sleep apnea syndrome).
- Severe hepatic insufficiency.
- Myasthenia gravis.
Drug Interactions
Opioids
Increased risk of profound sedation, respiratory depression, coma, and death.
Antacids
May delay absorption but do not affect bioavailability.
Alcohol and other CNS depressants
Potentiation of sedative effects.
CYP3A4 inhibitors (e.g., ketoconazole, fluvoxamine, grapefruit juice)
May increase bromazepam plasma concentrations and enhance its effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, confusion, lethargy, ataxia, hypotension, and respiratory depression. Severe cases may lead to coma and death. Treatment involves symptomatic and supportive measures, including airway management, intravenous fluids, and flumazenil (a benzodiazepine antagonist) if appropriate.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the first trimester, and during lactation. May cause neonatal depression, floppy infant syndrome, or withdrawal symptoms in the newborn. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved (in various countries)
Patent Status
Off-patent, generic available
Clinical Trials
Extensive clinical trials have established the efficacy and safety of bromazepam for its approved indications, especially for short-term anxiety management.
Lab Monitoring
- No routine lab monitoring is generally required for short-term use. For long-term use, periodic liver function tests may be considered.
Doctor Notes
- Exercise caution when prescribing to elderly patients due to increased sensitivity and risk of falls.
- Monitor for signs of misuse, abuse, and dependence, especially in patients with a history of substance abuse.
- Advise patients on the risks of concomitant use with opioids and alcohol.
Patient Guidelines
- Do not stop taking Bomaz suddenly without consulting your doctor, as this can lead to withdrawal symptoms.
- Avoid alcohol and other CNS depressants while taking this medication.
- This medicine can be habit-forming; use it exactly as prescribed for the shortest possible duration.
- Inform your doctor about all other medications you are taking, especially opioids.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Bomaz can cause drowsiness, dizziness, and impaired coordination. Do not drive or operate machinery until you are certain that your ability is not affected.
Lifestyle Advice
- Avoid driving or operating heavy machinery until you know how this medicine affects you.
- Report any unusual mood or behavior changes to your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.