Bonaid
Generic Name
Etodolac
Manufacturer
Delta Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bonaid 150 mg tablet | ৳ 1,500.00 | N/A |
Description
Overview of the medicine
Bonaid 150 mg tablet contains Etodolac, a non-steroidal anti-inflammatory drug (NSAID) primarily used for the relief of pain and inflammation. It is effective in treating conditions such as osteoarthritis, rheumatoid arthritis, and acute pain in musculoskeletal disorders.
Uses & Indications
Dosage
Adults
For osteoarthritis and rheumatoid arthritis, 300 mg two to three times daily, or 400 mg twice daily. For acute pain, 200-400 mg every 6-8 hours as needed, not exceeding 1200 mg/day. For Bonaid 150 mg, a common regimen would be 150 mg two to three times daily.
Elderly
Start with the lowest effective dose and monitor for adverse effects, especially gastrointestinal bleeding and renal function.
Renal_impairment
Use with caution. Dose reduction may be necessary in patients with mild to moderate renal impairment. Not recommended for severe renal impairment.
How to Take
Take orally, preferably with food or milk to reduce gastrointestinal irritation. Swallow the tablet whole with a glass of water.
Mechanism of Action
Etodolac exerts its anti-inflammatory, analgesic, and antipyretic effects by inhibiting cyclooxygenase (COX) enzymes, especially COX-2. This inhibition leads to a reduction in prostaglandin synthesis, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Analgesic effect begins within 30-60 minutes.
Excretion
Primarily excreted in urine (approx. 60% as metabolites), with a small amount excreted in feces.
Half life
Approximately 6-7 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver primarily via hydroxylation and glucuronidation.
Side Effects
Contraindications
- Known hypersensitivity to Etodolac or other NSAIDs (e.g., aspirin-induced asthma, urticaria, or allergic-type reactions)
- Active peptic ulceration or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, potentially leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, and epigastric pain. Gastrointestinal bleeding can occur. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management involves supportive and symptomatic treatment. Gastric lavage and/or activated charcoal may be considered if ingestion was recent.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Use with caution in other trimesters and during lactation, only if benefits outweigh risks. Consult a doctor before use if pregnant or breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
No longer under patent protection (generic available)
Clinical Trials
Extensive clinical trials have established the efficacy and safety profile of Etodolac for its approved indications, demonstrating its role in pain and inflammation management.
Lab Monitoring
- Complete blood count (CBC)
- Renal function tests (serum creatinine, BUN)
- Liver function tests (ALT, AST)
- Blood pressure monitoring
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration consistent with individual patient treatment goals.
- Monitor renal function, hepatic function, and blood pressure regularly, especially in elderly or high-risk patients and during long-term therapy.
- Be aware of the potential for serious cardiovascular and gastrointestinal adverse events associated with NSAID use.
Patient Guidelines
- Take Bonaid 150 mg with food or milk to minimize stomach upset.
- Do not exceed the prescribed dose or duration of treatment.
- Report any unusual bleeding, severe stomach pain, black or tarry stools, or swelling to your doctor immediately.
- Avoid concurrent use of other NSAIDs without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Bonaid may cause dizziness, drowsiness, or blurred vision in some individuals. If you experience these effects, avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Engage in moderate physical activity as advised by your doctor.
- Avoid smoking.
- Limit alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.