Boni-D
Generic Name
Calcium Carbonate + Vitamin D3
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| boni d 500 mg tablet | ৳ 6.00 | N/A |
Description
Overview of the medicine
Boni-D 500 mg Tablet is a combination of Calcium Carbonate and Vitamin D3 used for the prevention and treatment of calcium and vitamin D deficiencies, and to support bone health.
Uses & Indications
Dosage
Adults
Typically, 1 to 2 tablets daily, preferably with meals or as directed by the physician.
Elderly
No specific dosage adjustment required, but monitor for renal function and hypercalcemia risk.
Renal_impairment
Use with caution. Dosage adjustments may be necessary based on serum calcium and creatinine levels. Avoid in severe renal impairment.
How to Take
Take the tablet orally, preferably with food to enhance absorption and minimize gastrointestinal upset. Do not crush or chew the tablet; swallow whole.
Mechanism of Action
Calcium is an essential mineral for strong bones and teeth. Vitamin D3 helps the body absorb calcium from the digestive tract and maintain proper calcium levels in the blood.
Pharmacokinetics
Onset
The therapeutic effects on bone density are gradual and require consistent, long-term use.
Excretion
Calcium is primarily excreted via urine and feces. Vitamin D metabolites are excreted mainly in the bile and feces, with some renal excretion.
Half life
Vitamin D3 has a relatively long half-life, ranging from several days to weeks, depending on body stores. Calcium's half-life varies depending on its metabolic state.
Absorption
Calcium carbonate is absorbed in the small intestine, primarily by active transport and passive diffusion. Vitamin D3 is absorbed from the small intestine and requires bile salts for optimal absorption.
Metabolism
Vitamin D3 is hydroxylated in the liver to 25-hydroxyvitamin D [25(OH)D], which is then further hydroxylated in the kidneys to the active form, 1,25-dihydroxyvitamin D [1,25(OH)2D]. Calcium is not metabolized but its levels are tightly regulated.
Side Effects
Contraindications
- Hypersensitivity to Calcium Carbonate or Vitamin D3
- Hypercalcemia
- Hypercalciuria
- Severe renal impairment
- Kidney stones (history of)
Drug Interactions
Corticosteroids
Can decrease calcium absorption and increase calcium excretion, potentially necessitating higher doses of calcium and vitamin D.
Thiazide Diuretics
May increase serum calcium levels by decreasing calcium excretion in the kidneys, leading to hypercalcemia.
Tetracyclines & Fluoroquinolones
Calcium can chelate these antibiotics, reducing their absorption and effectiveness. Take these antibiotics at least 2-4 hours before or after Boni-D.
Cardiac Glycosides (e.g., Digoxin)
Hypercalcemia can increase the risk of digoxin toxicity. Monitor calcium levels closely.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypercalcemia) may include nausea, vomiting, constipation, abdominal pain, muscle weakness, fatigue, polydipsia, polyuria, and in severe cases, cardiac arrhythmias. Management involves discontinuing the medication, hydration, and medical supervision.
Pregnancy & Lactation
Boni-D is generally considered safe during pregnancy and lactation when taken at recommended doses, as calcium and vitamin D are essential for fetal bone development and infant health. However, always consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Calcium Carbonate or Vitamin D3
- Hypercalcemia
- Hypercalciuria
- Severe renal impairment
- Kidney stones (history of)
Drug Interactions
Corticosteroids
Can decrease calcium absorption and increase calcium excretion, potentially necessitating higher doses of calcium and vitamin D.
Thiazide Diuretics
May increase serum calcium levels by decreasing calcium excretion in the kidneys, leading to hypercalcemia.
Tetracyclines & Fluoroquinolones
Calcium can chelate these antibiotics, reducing their absorption and effectiveness. Take these antibiotics at least 2-4 hours before or after Boni-D.
Cardiac Glycosides (e.g., Digoxin)
Hypercalcemia can increase the risk of digoxin toxicity. Monitor calcium levels closely.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypercalcemia) may include nausea, vomiting, constipation, abdominal pain, muscle weakness, fatigue, polydipsia, polyuria, and in severe cases, cardiac arrhythmias. Management involves discontinuing the medication, hydration, and medical supervision.
Pregnancy & Lactation
Boni-D is generally considered safe during pregnancy and lactation when taken at recommended doses, as calcium and vitamin D are essential for fetal bone development and infant health. However, always consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Approximately 2-3 years from the date of manufacture.
Availability
Pharmacies, hospitals in Bangladesh
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Expired
Clinical Trials
Numerous clinical trials have established the efficacy and safety of calcium and vitamin D supplementation in preventing and treating osteoporosis and other bone-related conditions. Studies often focus on specific populations like postmenopausal women or the elderly.
Lab Monitoring
- Serum calcium levels (especially in patients with renal impairment or those on high doses)
- Serum 25-hydroxyvitamin D levels
- Renal function (serum creatinine)
Doctor Notes
- Advise patients on the importance of adherence to dosage and lifestyle modifications.
- Monitor serum calcium and vitamin D levels, especially in patients with pre-existing conditions affecting calcium metabolism or renal function.
- Counsel patients on potential drug and food interactions.
- Emphasize not exceeding the recommended daily allowance to avoid hypercalcemia.
Patient Guidelines
- Take Boni-D regularly as prescribed or directed.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications and supplements you are taking.
- Report any severe or persistent side effects to your doctor.
- Maintain a balanced diet and healthy lifestyle for optimal bone health.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Boni-D is not known to impair the ability to drive or operate machinery.
Lifestyle Advice
- Engage in regular weight-bearing exercises (e.g., walking, jogging) to strengthen bones.
- Ensure adequate sunlight exposure for natural vitamin D synthesis (while being sun-safe).
- Maintain a balanced diet rich in calcium and vitamin D (e.g., dairy products, leafy greens, fortified foods).
- Avoid excessive alcohol consumption and smoking, as they can negatively impact bone density.
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