Boni-LG
Generic Name
Boni-LG 500 mg Tablet
Manufacturer
MediTop Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| boni lg 500 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Boni-LG 500 mg Tablet is a broad-spectrum antibiotic used to treat various bacterial infections including those of the respiratory tract, urinary tract, skin, and soft tissues.
Uses & Indications
Dosage
Adults
For most infections, 500 mg once daily or 250 mg twice daily. Severe infections may require higher doses as prescribed by a physician.
Elderly
No specific dose adjustment is required for elderly patients with normal renal function. Monitor renal function in elderly.
Renal_impairment
For creatinine clearance (CrCl) 30-50 mL/min, 250 mg once daily. For CrCl < 30 mL/min, 250 mg every 48 hours or as advised by physician.
How to Take
Take Boni-LG 500 mg Tablet orally with or without food. It is important to complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
Mechanism of Action
Boni-LG inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial lysis and death. It has a bactericidal effect against susceptible organisms.
Pharmacokinetics
Onset
Within 1-2 hours of oral administration.
Excretion
Primarily renal excretion, with 60-80% of the unchanged drug recovered in urine within 24 hours. Some biliary excretion also occurs.
Half life
Approximately 2-3 hours in adults with normal renal function.
Absorption
Well absorbed orally; bioavailability approximately 60-70%. Peak plasma concentrations are reached within 2-3 hours after administration.
Metabolism
Undergoes minimal hepatic metabolism. The majority of the drug is excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cephalosporins or any component of Boni-LG.
- History of severe hypersensitivity reactions (e.g., anaphylaxis, severe skin reactions) to any other beta-lactam antibacterial agents (e.g., penicillins, carbapenems).
Drug Interactions
Probenecid
Increases Boni-LG plasma levels by decreasing its renal tubular secretion, prolonging its half-life and increasing exposure.
Aminoglycosides
Concurrent use with aminoglycosides may increase the risk of nephrotoxicity. Monitor renal function closely.
Oral Anticoagulants (e.g., Warfarin)
Concomitant use may potentiate the anticoagulant effect of warfarin. Monitor INR regularly and adjust anticoagulant dose if necessary.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for Boni-LG. Hemodialysis may be useful in accelerating its elimination from the body.
Pregnancy & Lactation
Pregnancy Category B. Use Boni-LG during pregnancy only if clearly needed. Boni-LG is excreted in breast milk in small amounts; use with caution in breastfeeding mothers. Consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to cephalosporins or any component of Boni-LG.
- History of severe hypersensitivity reactions (e.g., anaphylaxis, severe skin reactions) to any other beta-lactam antibacterial agents (e.g., penicillins, carbapenems).
Drug Interactions
Probenecid
Increases Boni-LG plasma levels by decreasing its renal tubular secretion, prolonging its half-life and increasing exposure.
Aminoglycosides
Concurrent use with aminoglycosides may increase the risk of nephrotoxicity. Monitor renal function closely.
Oral Anticoagulants (e.g., Warfarin)
Concomitant use may potentiate the anticoagulant effect of warfarin. Monitor INR regularly and adjust anticoagulant dose if necessary.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for Boni-LG. Hemodialysis may be useful in accelerating its elimination from the body.
Pregnancy & Lactation
Pregnancy Category B. Use Boni-LG during pregnancy only if clearly needed. Boni-LG is excreted in breast milk in small amounts; use with caution in breastfeeding mothers. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive Phase III clinical trials demonstrated Boni-LG's efficacy and safety in treating various bacterial infections, showing non-inferiority compared to existing broad-spectrum antibiotics.
Lab Monitoring
- Routine monitoring of renal function (serum creatinine, BUN) is recommended, especially in patients with pre-existing renal impairment or during prolonged therapy.
- Liver function tests (ALT, AST) may be monitored if clinically indicated.
Doctor Notes
- Emphasize the importance of completing the full prescribed course to prevent resistance.
- Advise patients on potential GI side effects and when to seek immediate medical attention (e.g., severe diarrhea, allergic reactions).
- Consider dose adjustment for patients with significant renal impairment.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor. Do not alter the dose or stop treatment prematurely.
- Even if you feel better, complete the full course of antibiotics to prevent recurrence and antibiotic resistance.
- Report any severe or persistent side effects to your doctor immediately.
- Avoid self-medication and share your complete medical history with your doctor.
Missed Dose Advice
If you miss a dose of Boni-LG, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Boni-LG may cause dizziness or lightheadedness in some patients. Patients should be cautioned about driving or operating machinery until they know how the drug affects them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol consumption during the treatment period as it may exacerbate side effects.
- Practice good hygiene to prevent the spread of infection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.