Bredicon
Generic Name
Prednisone
Manufacturer
UniMed UniHealth
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bredicon 0075 mg tablet | ৳ 60.20 | N/A |
Description
Overview of the medicine
Bredicon (Prednisone) is a synthetic corticosteroid used for its potent anti-inflammatory and immunosuppressive effects. It is primarily used to treat a wide range of conditions including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.
Uses & Indications
Dosage
Adults
Dosage varies greatly depending on the condition and severity. Typical starting dose for inflammatory conditions is 5-60 mg daily, often tapered down over time. Should always be individualized by a physician.
Elderly
Consider lower starting doses and slower titration due to increased risk of side effects. Monitor closely for adverse reactions.
Renal_impairment
No specific dose adjustment for mild to moderate renal impairment. Use with caution in severe renal failure.
How to Take
Take orally, usually once daily, with food or milk to minimize gastrointestinal irritation. It is often recommended to take the full daily dose in the morning.
Mechanism of Action
Prednisone works by binding to specific glucocorticoid receptors within target cells, leading to changes in gene expression. This results in the inhibition of various inflammatory mediators, suppression of immune responses, and stabilization of cell membranes, ultimately reducing inflammation and immune activity.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within 1 to 2 hours, peak effect within 1-2 days of continuous therapy.
Excretion
Excreted mainly in the urine, predominantly as inactive metabolites.
Half life
Prednisolone half-life is approximately 18-36 hours (biological half-life), plasma half-life is 2-4 hours.
Absorption
Well absorbed orally; rapidly converted to active prednisolone in the liver.
Metabolism
Primarily metabolized in the liver to active prednisolone, which is then further metabolized.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisone or any component of the formulation
Drug Interactions
Warfarin
May potentiate or decrease anticoagulant effect.
NSAIDs (e.g., ibuprofen)
Increased risk of gastrointestinal ulcers and bleeding.
Diuretics (e.g., furosemide)
Increased potassium loss.
Phenytoin, Phenobarbital, Rifampicin
May reduce corticosteroid efficacy due to increased metabolism.
Antidiabetics (e.g., insulin, metformin)
May increase blood glucose levels, requiring dose adjustment of antidiabetic drugs.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include fluid retention, hypertension, and hyperglycemia. Management is primarily supportive and symptomatic. Chronic overdose can lead to Cushing's syndrome.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Prednisone is excreted in breast milk and may cause adverse effects in nursing infants; caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA (USA) and DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Prednisone has been extensively studied in numerous clinical trials for its efficacy in various inflammatory and autoimmune conditions since its introduction. Its widespread use is supported by decades of clinical evidence.
Lab Monitoring
- Blood glucose levels (especially in diabetics)
- Electrolyte levels (potassium)
- Bone mineral density (for long-term use)
- Adrenal function tests (if tapering)
Doctor Notes
- Emphasize the importance of gradual tapering to prevent adrenal crisis.
- Monitor blood pressure, blood glucose, and bone density regularly in patients on long-term therapy.
- Educate patients on symptoms of infection and adrenal insufficiency.
Patient Guidelines
- Do not stop taking prednisone abruptly, especially after prolonged use, as it can lead to withdrawal symptoms.
- Take with food or milk to reduce stomach upset.
- Report any unusual side effects or worsening of symptoms to your doctor.
- Carry an identification card indicating you are on corticosteroid therapy.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Prednisone may cause dizziness, vision changes, or mood disturbances. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a diet low in sodium and high in potassium.
- Ensure adequate intake of calcium and vitamin D to protect bone health.
- Engage in regular, moderate exercise to maintain muscle strength and bone density.
- Avoid exposure to people with contagious diseases.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.