Brezofil-SR
Generic Name
Acebrophylline Sustained Release
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| brezofil sr 400 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Brezofil-SR 400 mg tablet contains Acebrophylline, a bronchodilator with mucoregulatory properties. It is used to treat chronic obstructive pulmonary disease (COPD) and bronchial asthma.
Uses & Indications
Dosage
Adults
One 400 mg tablet once daily or twice daily, as directed by physician.
Elderly
Similar to adult dosage, but caution with renal/hepatic impairment.
Renal_impairment
Reduced dosage may be required. Consult physician.
How to Take
Swallow the tablet whole with water. Do not chew or crush. Can be taken with or without food.
Mechanism of Action
Acebrophylline works by inhibiting phosphodiesterase, leading to bronchodilation, and also has mucoregulatory and anti-inflammatory effects by stimulating surfactant production and decreasing mucus viscosity.
Pharmacokinetics
Onset
Within 30-60 minutes for bronchodilation.
Excretion
Primarily via urine as metabolites.
Half life
Approximately 4-8 hours.
Absorption
Well absorbed orally, peak plasma concentration achieved in 1-2 hours.
Metabolism
Extensively metabolized in the liver to various metabolites.
Side Effects
Contraindications
- Hypersensitivity to Acebrophylline or other xanthine derivatives
- Acute myocardial infarction
- Hypotension
- Severe hepatic or renal impairment
Drug Interactions
Phenytoin, Phenobarbital, Rifampicin
May decrease plasma levels of Acebrophylline.
Cimetidine, Erythromycin, Fluoroquinolones
May increase plasma levels of Acebrophylline.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, restlessness, seizures. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal.
Pregnancy & Lactation
Use with caution, only if clearly needed and under medical supervision. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Acebrophylline or other xanthine derivatives
- Acute myocardial infarction
- Hypotension
- Severe hepatic or renal impairment
Drug Interactions
Phenytoin, Phenobarbital, Rifampicin
May decrease plasma levels of Acebrophylline.
Cimetidine, Erythromycin, Fluoroquinolones
May increase plasma levels of Acebrophylline.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, restlessness, seizures. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal.
Pregnancy & Lactation
Use with caution, only if clearly needed and under medical supervision. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 years from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in chronic respiratory diseases.
Lab Monitoring
- Liver function tests (in patients with hepatic impairment)
- Renal function tests (in patients with renal impairment)
Doctor Notes
- Advise patients on proper inhaler technique if prescribed concurrently with inhaled bronchodilators.
- Monitor for signs of xanthine toxicity, especially if co-administered with drugs that inhibit its metabolism.
Patient Guidelines
- Take the medicine regularly as prescribed by your doctor.
- Do not stop taking this medicine without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or tremor in some individuals, so exercise caution while driving or operating machinery.
Lifestyle Advice
- Avoid smoking, as it can worsen respiratory conditions.
- Maintain a healthy lifestyle with balanced diet and regular exercise.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.