Brox
Generic Name
brox-6-mg-pediatric-drop
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| brox 6 mg pediatric drop | ৳ 30.00 | N/A |
Description
Overview of the medicine
Brox 6 mg Pediatric Drop contains Ambroxol Hydrochloride, a mucolytic agent used to treat respiratory diseases associated with viscous mucus. It helps to thin and loosen mucus in the airways, making it easier to cough up.
Uses & Indications
Dosage
Adults
Not typically prescribed for adults; adult formulations available.
Elderly
Not typically prescribed for elderly; adult formulations available.
Renal_impairment
Use with caution in pediatric patients with severe renal impairment; dose adjustment may be necessary. Consult a physician.
Pediatric_drops_2_5_years
1 mL (6 mg) twice daily.
Pediatric_drops_infants_0_2_years
0.5 mL (3 mg) twice daily.
How to Take
Administer orally using the provided calibrated dropper. Can be taken with or without food. Ensure accurate measurement of the prescribed dose.
Mechanism of Action
Ambroxol is a mucolytic that enhances the production of pulmonary surfactant and stimulates ciliary activity. This leads to an increase in mucociliary clearance, facilitating the removal of bronchial secretions.
Pharmacokinetics
Onset
Starts to act within 30 minutes after oral administration.
Excretion
Mainly renal (approximately 90%), with about 10% excreted as unchanged drug.
Half life
Approximately 7-12 hours for the parent drug, prolonged in severe renal impairment.
Absorption
Rapidly and completely absorbed after oral administration, with peak plasma concentrations reached within 1-2.5 hours.
Metabolism
Primarily hepatic, with extensive first-pass metabolism. Metabolized to various inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to ambroxol hydrochloride or any component of the formulation.
- Rare hereditary conditions that may be incompatible with an excipient of the product (e.g., fructose intolerance if sorbitol is present).
Drug Interactions
Antitussives
Concomitant use with antitussives (cough suppressants) is not recommended as it may lead to a dangerous accumulation of secretions due to the impaired cough reflex.
Antibiotics (e.g., Amoxicillin, Cefuroxime, Erythromycin, Doxycycline)
Ambroxol may increase the penetration of certain antibiotics into bronchial secretions, potentially enhancing their therapeutic effect.
Storage
Store below 30°C, in a dry place, away from light. Do not freeze.
Overdose
Symptoms of overdose are generally mild and may include gastrointestinal disturbances. Treatment is symptomatic and supportive. Induce vomiting or perform gastric lavage if overdose is recent and significant.
Pregnancy & Lactation
Not recommended during the first trimester of pregnancy. Use with caution during the second and third trimesters only if clearly necessary and after careful risk-benefit assessment. Ambroxol is excreted into breast milk; therefore, its use during lactation should be avoided or breast-feeding should be discontinued.
Side Effects
Contraindications
- Hypersensitivity to ambroxol hydrochloride or any component of the formulation.
- Rare hereditary conditions that may be incompatible with an excipient of the product (e.g., fructose intolerance if sorbitol is present).
Drug Interactions
Antitussives
Concomitant use with antitussives (cough suppressants) is not recommended as it may lead to a dangerous accumulation of secretions due to the impaired cough reflex.
Antibiotics (e.g., Amoxicillin, Cefuroxime, Erythromycin, Doxycycline)
Ambroxol may increase the penetration of certain antibiotics into bronchial secretions, potentially enhancing their therapeutic effect.
Storage
Store below 30°C, in a dry place, away from light. Do not freeze.
Overdose
Symptoms of overdose are generally mild and may include gastrointestinal disturbances. Treatment is symptomatic and supportive. Induce vomiting or perform gastric lavage if overdose is recent and significant.
Pregnancy & Lactation
Not recommended during the first trimester of pregnancy. Use with caution during the second and third trimesters only if clearly necessary and after careful risk-benefit assessment. Ambroxol is excreted into breast milk; therefore, its use during lactation should be avoided or breast-feeding should be discontinued.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Expired
Clinical Trials
Ambroxol has been widely studied in numerous clinical trials demonstrating its efficacy and safety as a mucolytic agent across various respiratory conditions in pediatric and adult populations.
Lab Monitoring
- Routine lab monitoring is not typically required for ambroxol hydrochloride therapy.
Doctor Notes
- Emphasize accurate dosing for infants and young children using the provided dropper.
- Advise parents to seek medical attention if symptoms worsen or if a rash develops.
- Ensure proper hydration to enhance mucolytic effect.
Patient Guidelines
- Always use the provided dropper for accurate dosing. Do not use household spoons.
- Do not exceed the recommended dose.
- If symptoms persist or worsen, consult a doctor.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Ambroxol is not known to impair the ability to drive or operate machinery. However, if any side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain adequate hydration to help thin mucus.
- Avoid exposure to smoke and irritants that can worsen respiratory conditions.
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Global Brand Names
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