Broxidil
Generic Name
Ambroxol Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| broxidil 15 mg syrup | ৳ 40.00 | N/A |
Description
Overview of the medicine
Ambroxol (Broxidil) is a mucolytic agent used to treat respiratory diseases associated with viscid mucus. It helps to thin and loosen mucus, making it easier to clear from the airways and thereby relieving cough.
Uses & Indications
Dosage
Adults
10 ml (30 mg) 3 times daily.
Children_2_5_years
2.5 ml (7.5 mg) 3 times daily.
Children_6_12_years
5 ml (15 mg) 2-3 times daily.
Infants_up_to_2_years
2.5 ml (7.5 mg) 2 times daily.
How to Take
Administer orally with or without food. Measure the dose accurately using the provided measuring cup or spoon. Drink plenty of fluids to help thin the mucus.
Mechanism of Action
Ambroxol acts as a mucolytic by depolymerizing mucopolysaccharides directly as well as by stimulating serous gland activity, leading to less viscous mucus. It also enhances ciliary activity, promoting mucociliary clearance, and stimulates the production of pulmonary surfactant.
Pharmacokinetics
Onset
Within 30 minutes.
Excretion
Mainly through the kidneys (approx. 90% as metabolites).
Half life
Approximately 7-12 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract.
Metabolism
Primarily in the liver to various conjugated and unconjugated metabolites.
Side Effects
Contraindications
- Hypersensitivity to Ambroxol or any other component of the formulation.
- Severe kidney or liver impairment (use with caution).
Drug Interactions
Antitussives (cough suppressants)
Concomitant use with antitussives is not recommended as it may lead to a dangerous accumulation of secretions due to the impaired cough reflex.
Antibiotics (e.g., Amoxicillin, Cefuroxime, Erythromycin)
Ambroxol can increase the penetration of these antibiotics into bronchial secretions, potentially enhancing their effect.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms may include nausea, vomiting, diarrhea, and epigastric pain. Management is supportive and symptomatic; gastric lavage or forced emesis may be considered soon after ingestion.
Pregnancy & Lactation
Use with caution during pregnancy, especially in the first trimester. Consult a doctor. Generally considered safe during lactation, but medical advice is recommended.
Side Effects
Contraindications
- Hypersensitivity to Ambroxol or any other component of the formulation.
- Severe kidney or liver impairment (use with caution).
Drug Interactions
Antitussives (cough suppressants)
Concomitant use with antitussives is not recommended as it may lead to a dangerous accumulation of secretions due to the impaired cough reflex.
Antibiotics (e.g., Amoxicillin, Cefuroxime, Erythromycin)
Ambroxol can increase the penetration of these antibiotics into bronchial secretions, potentially enhancing their effect.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms may include nausea, vomiting, diarrhea, and epigastric pain. Management is supportive and symptomatic; gastric lavage or forced emesis may be considered soon after ingestion.
Pregnancy & Lactation
Use with caution during pregnancy, especially in the first trimester. Consult a doctor. Generally considered safe during lactation, but medical advice is recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date, varies by manufacturer.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA and other regulatory bodies
Patent Status
Generic (patent expired)
WHO Essential Medicine
YesClinical Trials
Ambroxol has been widely studied in numerous clinical trials, demonstrating its efficacy and safety as a mucolytic agent in various acute and chronic respiratory conditions.
Lab Monitoring
- No specific routine lab monitoring is required for Ambroxol.
Doctor Notes
- Advise patients to drink adequate fluids to enhance mucolytic action.
- Monitor for hypersensitivity reactions, especially skin rashes, and discontinue if observed.
- Not recommended for persistent cough without thorough medical evaluation to determine the underlying cause.
Patient Guidelines
- Do not exceed the recommended dose.
- Drink plenty of fluids to help thin mucus.
- If symptoms persist for more than 7 days, or worsen, consult a doctor immediately.
- Report any skin rash or allergic reactions to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose to make up for a missed one.
Driving Precautions
Ambroxol has no known effects on the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid such activities.
Lifestyle Advice
- Avoid smoking, as it irritates the airways and worsens cough and mucus production.
- Maintain good hydration by drinking adequate water throughout the day.
- Avoid irritants like dust, pollen, and strong fumes if they trigger respiratory symptoms.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.