Medicine Information

Buprocaine

Name: Buprocaine
Brand: Buprocaine
Rating: 4.5 (117 reviews)

Eye Drop (Ophthalmic Solution)0.4% (4 mg/mL)Topical Ophthalmic AnestheticsATC: S01HAxx

Generic Name

Buprocaine 0.4% Ophthalmic Solution

Manufacturer

Ocular Pharma Inc.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
buprocaine 04 eye drop	৳ 100.30	N/A

Description

Overview of the medicine

Buprocaine 0.4% Eye Drop is a topical ophthalmic anesthetic used to temporarily numb the surface of the eye for diagnostic procedures or minor surgeries.

Uses & Indications

Ophthalmic anesthesia for short corneal and conjunctival procedures (e.g., tonometry, removal of foreign bodies, gonioscopy).

Anesthesia prior to minor ophthalmic surgery.

Dosage

Adults

1 to 2 drops in the affected eye(s) as needed for the procedure. Additional drops may be administered to maintain anesthesia.

Elderly

No specific dosage adjustment required; same as adults.

Renal_impairment

No specific dosage adjustment needed for topical ophthalmic use.

How to Take

For ophthalmic use only. Instill drops into the conjunctival sac. Avoid touching the dropper tip to the eye or any other surface to prevent contamination.

Mechanism of Action

Buprocaine works by blocking the generation and conduction of nerve impulses, primarily by preventing the influx of sodium ions through voltage-gated sodium channels in the nerve membrane, thereby stabilizing the neuronal membrane.

Pharmacokinetics

Onset

30-60 seconds.

Excretion

Metabolites excreted primarily via urine.

Half life

Not well-defined for topical ophthalmic application due to local action.

Absorption

Minimal systemic absorption following topical ophthalmic administration; primarily acts locally.

Metabolism

Likely metabolized by plasma pseudocholinesterases (if an ester) or hepatic enzymes (if an amide).

Side Effects

Contraindications

Hypersensitivity to buprocaine or any other local anesthetics of the same chemical class.
Known allergy to any component of the formulation.

Drug Interactions

Sulfonamides

If buprocaine is an ester-type anesthetic, it may reduce the antibacterial activity of sulfonamides.

Anticholinesterase agents

May inhibit the metabolism of buprocaine if it's an ester-type anesthetic, potentially prolonging its effects or increasing systemic toxicity.

Storage

Store at room temperature (15-30°C). Protect from light. Do not freeze.

Overdose

Systemic overdose is highly unlikely with topical ophthalmic use due to minimal systemic absorption. Local irritation or transient corneal damage may occur with excessive or prolonged use.

Pregnancy & Lactation

Use during pregnancy or lactation only if the potential benefit outweighs the potential risk to the fetus or infant. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 mL bottle15 mL bottle

Shelf Life

24 months (unopened); discard 28 days after opening.

Availability

Pharmacies, Hospitals

Approval Status

Approved (Hypothetical)

Patent Status

Generic available

Clinical Trials

Extensive clinical trials support the efficacy and safety of topical ophthalmic anesthetics for their indicated uses.

Lab Monitoring

No specific laboratory monitoring is required for routine topical ophthalmic use.

Doctor Notes

Emphasize the importance of not prescribing for patient self-administration due to risks of prolonged use.
Inform patients that the eye will be numb; advise against rubbing or touching the eye.

Patient Guidelines

This medication is for professional use only and should not be self-administered.
Do not touch the dropper tip to the eye or any other surface to avoid contamination.
Do not wear contact lenses during or immediately after administration.
Avoid rubbing or touching the eye while it is numb, as this can cause injury.