Burat-CR
Generic Name
burat-cr-50-mg-tablet
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| burat cr 50 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Burat-CR 50 mg tablet is a controlled-release formulation of a hypothetical SSRI, used for the treatment of major depressive disorder and various anxiety disorders. Its controlled-release nature ensures sustained therapeutic levels and improved patient compliance.
Uses & Indications
Dosage
Adults
Initially 50 mg once daily, preferably in the morning. May be increased to 100 mg daily after several weeks based on response and tolerability.
Elderly
Lower initial dose (e.g., 25 mg once daily) may be considered, with gradual titration.
Renal_impairment
No dosage adjustment required for mild to moderate impairment; caution advised in severe impairment.
How to Take
Swallow the tablet whole with water, with or without food. Do not crush, chew, or break the tablet.
Mechanism of Action
Acts as a selective serotonin reuptake inhibitor (SSRI), increasing serotonin levels in the brain to improve mood and reduce anxiety.
Pharmacokinetics
Onset
Initial therapeutic effects within 1-2 weeks; full effects may take 4-6 weeks.
Excretion
Primarily excreted in urine and feces as metabolites.
Half life
Approximately 22-30 hours, allowing for once-daily dosing.
Absorption
Well absorbed from the gastrointestinal tract, with peak plasma concentrations reached in 6-12 hours due to controlled release.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to the active substance or excipients
- Concomitant use with MAOIs
- Severe hepatic impairment
Drug Interactions
MAOIs
May lead to serotonin syndrome; contra-indicated.
Triptans
Increased risk of serotonin syndrome; use with caution.
Warfarin
May increase anticoagulant effect; monitor INR.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, dizziness, tachycardia, tremor, and somnolence. Management involves supportive care and symptomatic treatment. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to the active substance or excipients
- Concomitant use with MAOIs
- Severe hepatic impairment
Drug Interactions
MAOIs
May lead to serotonin syndrome; contra-indicated.
Triptans
Increased risk of serotonin syndrome; use with caution.
Warfarin
May increase anticoagulant effect; monitor INR.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, dizziness, tachycardia, tremor, and somnolence. Management involves supportive care and symptomatic treatment. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent pending
Clinical Trials
Ongoing post-marketing surveillance studies for long-term efficacy and safety.
Lab Monitoring
- Baseline liver function tests
- Serum sodium levels (especially in elderly)
- INR for patients on anticoagulants
Doctor Notes
- Advise patients on delayed onset of action and importance of adherence.
- Monitor for signs of serotonin syndrome, especially when co-administered with other serotonergic agents.
- Counsel patients on potential withdrawal symptoms upon discontinuation.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any unusual mood changes or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.
Driving Precautions
May cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Practice stress management techniques.
- Avoid alcohol while on this medication.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.