Butapan
Generic Name
Hyoscine Butylbromide 20 mg Injection
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| butapan 20 mg injection | ৳ 7.91 | N/A |
Description
Overview of the medicine
Hyoscine Butylbromide is an antispasmodic medication used to relieve spasms and associated pain in the gastrointestinal, biliary, and genitourinary tracts.
Uses & Indications
Dosage
Adults
20 mg intramuscularly (IM) or slow intravenously (IV), repeated after 30 minutes if necessary. Maximum daily dose should not exceed 100 mg.
Elderly
Same as adult dosage, but use with caution and monitor for anticholinergic side effects.
Renal_impairment
No specific dose adjustment is generally required, but caution is advised in severe cases.
How to Take
Administer by intramuscular (IM) or slow intravenous (IV) injection, usually by a healthcare professional.
Mechanism of Action
It works by selectively blocking muscarinic acetylcholine receptors on the smooth muscle cells of the gastrointestinal tract, leading to relaxation of the muscles and reduction of spasms.
Pharmacokinetics
Onset
Rapid onset of action, typically within minutes after IV or IM administration.
Excretion
Primarily excreted via urine and feces.
Half life
Plasma half-life is short (a few hours), but local effect may last longer.
Absorption
Rapid absorption after intramuscular (IM) or intravenous (IV) injection. Oral absorption is poor.
Metabolism
Partially metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Hyoscine Butylbromide or any component of the formulation
- Myasthenia gravis
- Megacolon
- Mechanical stenosis of the gastrointestinal tract
- Paralytic or obstructive ileus
- Urinary retention (e.g., prostatic hypertrophy)
- Narrow-angle glaucoma
- Tachyarrhythmia
Drug Interactions
Beta-agonists
May increase the heart-rate-accelerating effect of beta-agonists.
Dopamine antagonists (e.g., metoclopramide)
Antagonistic effects on gastrointestinal motility.
Tricyclic antidepressants, antihistamines, quinidine, amantadine, disopyramide
May potentiate the anticholinergic effects of Hyoscine Butylbromide.
Storage
Store below 25°C. Protect from light. Do not freeze.
Overdose
Symptoms of overdose include dry mouth, blurred vision, tachycardia, urinary retention, and skin redness. Management is symptomatic and supportive. Physostigmine may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy, only if clearly needed and after consulting a doctor. Small amounts may be excreted in breast milk; generally considered safe, but monitor the infant for any adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Hyoscine Butylbromide has been extensively studied for its efficacy in various spasmodic conditions, demonstrating consistent relief of acute abdominal pain and spasms.
Lab Monitoring
- Routine laboratory monitoring is generally not required for this medication.
Doctor Notes
- Administer IV injection slowly to avoid transient tachycardia and hypotension.
- Exercise caution in patients with prostatic hypertrophy or paralytic ileus due to the risk of urinary retention and bowel obstruction.
- Not recommended for use in children under 6 years of age for colic.
Patient Guidelines
- This medication is typically administered by a healthcare professional.
- Report any unusual or severe side effects immediately to your doctor or nurse.
- Avoid driving or operating machinery if you experience blurred vision or dizziness.
Missed Dose Advice
As this is an injection administered by a healthcare professional, missed doses are unlikely in a controlled setting. If for outpatient use, contact your doctor for advice.
Driving Precautions
This medication may cause blurred vision or dizziness. Patients should be advised not to drive or operate machinery until their vision and mental alertness are clear.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid alcohol if experiencing dizziness or blurred vision.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.