Cabanib
Generic Name
Cabozantinib 60 mg capsule
Manufacturer
Beacon Pharmaceuticals Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cabanib 60 mg capsule | ৳ 350.00 | N/A |
Description
Overview of the medicine
Cabanib (Cabozantinib) is a kinase inhibitor indicated for various types of cancer. It targets multiple receptor tyrosine kinases (RTKs) involved in tumor growth, metastasis, and angiogenesis.
Uses & Indications
Dosage
Adults
MTC/HCC/DTC: 60 mg orally once daily. RCC: 60 mg orally once daily (dose adjustments for adverse reactions may be required).
Elderly
No specific dosage adjustment required based on age alone.
Renal_impairment
No dosage adjustment for mild to moderate impairment. Not studied in severe renal impairment.
How to Take
Take orally with or without food. Do not eat for at least 2 hours before and 1 hour after taking Cabanib. Swallow capsules whole. Do not open, crush, or chew capsules.
Mechanism of Action
Cabozantinib inhibits the tyrosine kinase activity of MET, VEGFR1, VEGFR2, VEGFR3, AXL, RET, ROS1, TYRO3, MER, KIT, TRKB, and FLT3. These kinases are involved in oncogenesis, metastasis, tumor angiogenesis, and the maintenance of the tumor microenvironment.
Pharmacokinetics
Onset
Not precisely defined for kinase inhibitors; clinical effects observed over weeks.
Excretion
Primarily via feces (81%), with a minor amount via urine (10%).
Half life
Approximately 99 hours.
Absorption
Oral administration. Tmax is 2-4 hours. High-fat meal increases AUC by 42% and Cmax by 29%.
Metabolism
Primarily hepatic, mainly by CYP3A4.
Side Effects
Contraindications
- •Known hypersensitivity to cabozantinib or any component of the formulation.
Drug Interactions
Strong CYP3A4 inducers (e.g., rifampicin, phenytoin)
May decrease cabozantinib exposure. Avoid co-administration or increase cabozantinib dose.
Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
May increase cabozantinib exposure. Avoid co-administration or reduce cabozantinib dose.
Storage
Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Protect from moisture.
Overdose
No specific antidote. Management involves symptomatic and supportive care.
Pregnancy & Lactation
Pregnancy: May cause fetal harm. Advise females of reproductive potential to use effective contraception during treatment and for 4 months after the last dose. Lactation: Advise women not to breastfeed during treatment and for 4 months after the last dose.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months.
Availability
Hospitals, specialized pharmacies
Approval Status
FDA Approved
Patent Status
Patented
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Global Brand Names
International brand names for this medicine
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