Caberol
Generic Name
Cabergoline
Manufacturer
ACME Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| caberol 05 mg tablet | ৳ 80.00 | ৳ 160.00 |
Description
Overview of the medicine
Caberol 0.5 mg Tablet contains cabergoline, a dopamine receptor agonist used to treat hyperprolactinemic disorders, which include amenorrhea, oligomenorrhea, anovulation, and galactorrhea. It works by lowering prolactin levels.
Uses & Indications
Dosage
Adults
Initial dose for hyperprolactinemic disorders: 0.25 mg twice a week. Dosage may be increased by 0.25 mg increments twice weekly at monthly intervals until an optimal therapeutic response is achieved. Max dose is typically 1 mg twice a week. For suppression of lactation: 1 mg as a single dose.
Elderly
No specific dose adjustment is generally required, but caution should be exercised due to potential age-related decrease in renal or hepatic function.
Renal_impairment
No specific dose adjustment is required in patients with renal impairment, but caution is advised due to limited data.
How to Take
Take orally, preferably with meals to reduce the incidence of nausea, at the specified frequency (e.g., twice weekly).
Mechanism of Action
Cabergoline is a synthetic ergot derivative and a long-acting dopamine D2 receptor agonist. It directly stimulates D2 receptors on lactotroph cells in the anterior pituitary gland, thereby inhibiting prolactin secretion. Lowering prolactin levels helps to normalize menstrual cycles, fertility, and milk production.
Pharmacokinetics
Onset
Prolactin-lowering effect seen within 3 hours.
Excretion
Mainly excreted in feces (60%) and urine (22%) as metabolites; less than 4% is excreted unchanged in urine.
Half life
Approximately 63 to 68 hours in healthy volunteers and 79 to 115 hours in hyperprolactinemic patients.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 0.5 to 4 hours.
Metabolism
Extensively metabolized in the liver, primarily via hydrolysis. Cytochrome P450 involvement is minimal.
Side Effects
Contraindications
- Hypersensitivity to cabergoline or any ergot alkaloid.
- Uncontrolled hypertension.
- History of pulmonary, pericardial, or retroperitoneal fibrotic disorders.
- Cardiac valvulopathy (history of or evidence of valvular heart disease determined by echocardiography).
Drug Interactions
Other ergot derivatives
Increased risk of ergot-related adverse events.
Macrolide antibiotics (e.g., erythromycin)
May increase systemic exposure to cabergoline, use with caution.
Dopamine antagonists (e.g., phenothiazines, butyrophenones, thioxanthenes, metoclopramide)
May reduce the prolactin-lowering effect of cabergoline.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are likely to be those of overstimulation of dopamine receptors, such as nausea, vomiting, gastric complaints, orthostatic hypotension, confusion, psychosis, or hallucinations. Treatment involves general supportive measures and removal of unabsorbed drug, and dopamine antagonist administration if necessary.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and the potential benefits outweigh the potential risks. Not recommended during lactation as it inhibits milk production and its excretion into breast milk is unknown.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated cabergoline's efficacy in normalizing prolactin levels and improving associated symptoms in patients with hyperprolactinemia.
Lab Monitoring
- Serum prolactin levels (regularly to monitor therapeutic response and adjust dose).
- Blood pressure (especially at initiation due to orthostatic hypotension risk).
- Echocardiogram (before and periodically during long-term treatment to monitor for valvulopathy).
Doctor Notes
- Assess cardiac valvular status prior to initiation and periodically during long-term therapy with echocardiography.
- Monitor blood pressure, especially for orthostatic hypotension, at the start of treatment and during dose escalation.
- Educate patients on symptoms of fibrotic reactions (e.g., dyspnea, persistent cough, chest pain, renal insufficiency) and to report them promptly.
Patient Guidelines
- Take exactly as prescribed by your doctor, usually twice a week.
- Take with food to minimize stomach upset.
- Do not stop taking the medicine abruptly without consulting your doctor.
- Report any new or worsening symptoms, especially shortness of breath, persistent cough, or swelling of ankles, to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness, especially at the start of treatment. Patients should be warned not to drive or operate machinery if they experience these symptoms.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid sudden changes in posture to minimize orthostatic hypotension.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.