Caberol
Generic Name
Cabergoline
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| caberol 05 mg tablet | ৳ 80.00 | ৳ 160.00 |
Description
Overview of the medicine
Caberol (Cabergoline) is a dopamine receptor agonist used to treat conditions associated with high levels of the hormone prolactin (hyperprolactinemia). It works by decreasing the amount of prolactin released from the pituitary gland.
Uses & Indications
Dosage
Adults
For hyperprolactinemia, initial dose is 0.25 mg orally twice a week. Dosage may be increased by 0.25 mg twice a week at monthly intervals as needed, up to a maximum of 1 mg twice a week. For inhibition of lactation, 1 mg as a single dose. For suppression of lactation, 0.25 mg twice daily for 2 days.
Elderly
No specific dose adjustment required, but caution is advised due to potential age-related decrease in renal function.
Renal_impairment
No specific dose adjustment required for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Caberol tablets should be taken orally, preferably with food, to minimize gastrointestinal side effects. It is usually taken twice a week on specific days (e.g., Monday and Thursday).
Mechanism of Action
Cabergoline is a synthetic ergot derivative and a potent, long-acting dopamine D2 receptor agonist. It selectively binds to D2 receptors on lactotroph cells in the anterior pituitary gland, thereby inhibiting the synthesis and secretion of prolactin.
Pharmacokinetics
Onset
Prolactin-lowering effect starts within 3 hours.
Excretion
Excreted primarily in feces (about 60%) and urine (about 22%).
Half life
Approximately 63-68 hours in healthy volunteers and hyperprolactinemic patients.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-3 hours.
Metabolism
Extensively metabolized in the liver via hydrolysis of the acylurea bond and N-dealkylation.
Side Effects
Contraindications
- •Hypersensitivity to cabergoline or any other ergot derivatives
- •Uncontrolled hypertension
- •History of pulmonary, pericardial, or retroperitoneal fibrotic disorders
- •Valvular heart disease (confirmed by echocardiography prior to treatment)
- •Pregnancy-induced hypertension (preeclampsia, eclampsia)
- •Postpartum hypertension
Drug Interactions
Antihypertensive agents
Additive hypotensive effects; monitor blood pressure.
Other ergot derivatives
Increased risk of ergot-related side effects.
Dopamine antagonists (e.g., phenothiazines, butyrophenones, thioxanthenes, metoclopramide)
May reduce the prolactin-lowering effect of cabergoline.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nasal congestion, syncope, hallucinations, or psychosis. Treatment is symptomatic and supportive. Gastric lavage and dopamine antagonist administration may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and the potential benefits outweigh the potential risks to the fetus. It is contraindicated in cases of pregnancy-induced hypertension. Cabergoline inhibits lactation and should not be used in mothers who choose to breastfeed unless clinically indicated to suppress lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, check product packaging for specific expiry date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by health authorities
Patent Status
Generic versions available
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Global Brand Names
International brand names for this medicine
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