Caffo
Generic Name
Paracetamol
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| caffo 500 mg tablet | ৳ 1.90 | ৳ 19.00 |
Description
Overview of the medicine
Caffo 500 mg Tablet contains Paracetamol, which is used to relieve mild to moderate pain and reduce fever. It works by blocking the production of certain chemical messengers that cause pain and fever.
Uses & Indications
Dosage
Adults
500-1000 mg (1-2 tablets) every 4-6 hours as needed, not to exceed 4000 mg (8 tablets) in 24 hours.
Elderly
Similar to adults; caution advised in patients with compromised hepatic or renal function.
Renal_impairment
Dose interval may need to be extended in severe renal impairment (e.g., 500 mg every 8-12 hours).
How to Take
Administer orally with water, with or without food. Do not exceed the recommended dose or duration.
Mechanism of Action
Paracetamol primarily inhibits prostaglandin synthesis in the central nervous system (CNS), resulting in analgesic (pain relief) and antipyretic (fever reduction) effects. It has weak peripheral anti-inflammatory activity.
Pharmacokinetics
Onset
Analgesic effect begins within 30-60 minutes; antipyretic effect within 30 minutes.
Excretion
Mainly excreted in urine as glucuronide and sulfate conjugates; less than 5% is excreted unchanged.
Half life
Plasma half-life is 1 to 4 hours, prolonged in hepatic dysfunction.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation, with a small amount by cytochrome P450 pathway.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Increases the risk of hepatotoxicity, especially with chronic excessive alcohol consumption.
Warfarin
May increase the anticoagulant effect of warfarin, increasing bleeding risk.
Cholestyramine
Reduces paracetamol absorption if taken within one hour.
Other hepatotoxic drugs
Concurrent use may increase the risk of liver damage.
Metoclopramide/Domperidone
Increases paracetamol absorption rate.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose can cause severe, potentially fatal liver damage. Symptoms include nausea, vomiting, abdominal pain. Management involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended therapeutic doses. However, always consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Increases the risk of hepatotoxicity, especially with chronic excessive alcohol consumption.
Warfarin
May increase the anticoagulant effect of warfarin, increasing bleeding risk.
Cholestyramine
Reduces paracetamol absorption if taken within one hour.
Other hepatotoxic drugs
Concurrent use may increase the risk of liver damage.
Metoclopramide/Domperidone
Increases paracetamol absorption rate.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose can cause severe, potentially fatal liver damage. Symptoms include nausea, vomiting, abdominal pain. Management involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended therapeutic doses. However, always consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from the date of manufacture.
Availability
Available in pharmacies, general stores
Approval Status
Approved (Generic)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Paracetamol has undergone extensive clinical trials over decades, establishing its efficacy and safety profile for pain and fever relief.
Lab Monitoring
- Liver function tests (in cases of suspected overdose or prolonged high-dose therapy)
- Renal function tests (in patients with pre-existing renal impairment)
Doctor Notes
- Emphasize strict adherence to maximum daily dosage to prevent hepatotoxicity.
- Advise patients with pre-existing liver conditions to consult before use.
- Not recommended for children under 6 years without medical advice.
Patient Guidelines
- Do not exceed the recommended dose in 24 hours.
- Avoid concurrent use of other paracetamol-containing products.
- Consult a doctor if pain or fever persists for more than a few days.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Paracetamol is generally not associated with drowsiness or impairment of driving ability.
Lifestyle Advice
- Stay hydrated, especially when having fever.
- Limit or avoid alcohol consumption while taking this medication.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.