Calcin-D
Generic Name
Calcium Carbonate + Vitamin D3
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| calcin d 500 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Calcin-D 500 mg Tablet is a combination medicine containing Calcium Carbonate and Vitamin D3 (Colecalciferol). It is used to prevent and treat calcium and vitamin D deficiencies, which are essential for maintaining healthy bones and teeth.
Uses & Indications
Dosage
Adults
Usually 1-2 tablets daily, or as directed by the physician. Should be taken with a meal.
Elderly
Similar to adult dosage, but caution should be exercised in patients with renal impairment or a history of kidney stones. Dosage adjustment may be required based on serum calcium and vitamin D levels.
Renal_impairment
Use with caution. Dosage may need to be reduced. Regular monitoring of serum calcium and phosphate levels is essential. Contraindicated in severe renal impairment.
How to Take
Oral administration. Tablets should be swallowed whole with water, preferably with a meal to enhance absorption and reduce gastric upset.
Mechanism of Action
Calcium is an essential mineral required for bone formation, muscle contraction, nerve transmission, and various cellular functions. Vitamin D3 facilitates the absorption of calcium from the gastrointestinal tract and its incorporation into bone, helping to maintain proper calcium and phosphate levels in the body.
Pharmacokinetics
Onset
Gradual, as bone mineral density changes take time.
Excretion
Unabsorbed calcium is excreted in feces. Absorbed calcium is primarily excreted via urine. Vitamin D3 metabolites are mainly excreted in bile and feces, with some renal excretion.
Half life
Elemental calcium has a complex disposition. Vitamin D3 has a half-life of several days to weeks, with active metabolites having varying half-lives.
Absorption
Calcium absorption from the GI tract is variable (20-30%) and occurs via active transport and passive diffusion, enhanced by Vitamin D3. Vitamin D3 is absorbed from the small intestine, primarily in the jejunum, and transported via chylomicrons.
Metabolism
Calcium is mainly deposited in bones. Vitamin D3 is hydroxylated in the liver to 25-hydroxyvitamin D3 (calcifediol) and then in the kidneys to the active form, 1,25-dihydroxyvitamin D3 (calcitriol).
Side Effects
Contraindications
- Hypercalcemia (high levels of calcium in the blood)
- Hypercalciuria (high levels of calcium in the urine)
- Hypervitaminosis D (excessive levels of Vitamin D)
- Severe renal impairment or kidney stones
- Hypersensitivity to calcium carbonate, Vitamin D3, or any component of the formulation
Drug Interactions
Bisphosphonates
Calcium can interfere with bisphosphonate absorption; take at least 30 minutes to 1 hour apart.
Corticosteroids
Can decrease calcium absorption.
Thiazide Diuretics
May increase the risk of hypercalcemia by reducing calcium excretion.
Digitalis Glycosides
Hypercalcemia can potentiate the effects of digitalis, leading to cardiac arrhythmias.
Tetracyclines & Fluoroquinolones
Calcium can reduce the absorption of these antibiotics; take at least 2-3 hours apart.
Thyroid Hormones (Levothyroxine)
Calcium can reduce absorption of levothyroxine; take at least 4 hours apart.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia (nausea, vomiting, constipation, abdominal pain, muscle weakness, polyuria, polydipsia, lethargy, confusion, and in severe cases, cardiac arrhythmias and coma). Management involves discontinuing the product, hydration, and medical supervision. In severe cases, corticosteroids or calcitonin may be used.
Pregnancy & Lactation
Calcin-D is generally considered safe and often recommended during pregnancy and lactation to meet increased calcium and vitamin D requirements, but only under the guidance of a physician. Excessive doses should be avoided.
Side Effects
Contraindications
- Hypercalcemia (high levels of calcium in the blood)
- Hypercalciuria (high levels of calcium in the urine)
- Hypervitaminosis D (excessive levels of Vitamin D)
- Severe renal impairment or kidney stones
- Hypersensitivity to calcium carbonate, Vitamin D3, or any component of the formulation
Drug Interactions
Bisphosphonates
Calcium can interfere with bisphosphonate absorption; take at least 30 minutes to 1 hour apart.
Corticosteroids
Can decrease calcium absorption.
Thiazide Diuretics
May increase the risk of hypercalcemia by reducing calcium excretion.
Digitalis Glycosides
Hypercalcemia can potentiate the effects of digitalis, leading to cardiac arrhythmias.
Tetracyclines & Fluoroquinolones
Calcium can reduce the absorption of these antibiotics; take at least 2-3 hours apart.
Thyroid Hormones (Levothyroxine)
Calcium can reduce absorption of levothyroxine; take at least 4 hours apart.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia (nausea, vomiting, constipation, abdominal pain, muscle weakness, polyuria, polydipsia, lethargy, confusion, and in severe cases, cardiac arrhythmias and coma). Management involves discontinuing the product, hydration, and medical supervision. In severe cases, corticosteroids or calcitonin may be used.
Pregnancy & Lactation
Calcin-D is generally considered safe and often recommended during pregnancy and lactation to meet increased calcium and vitamin D requirements, but only under the guidance of a physician. Excessive doses should be avoided.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Pharmacies, supermarkets
Approval Status
Approved in most countries (often OTC)
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have established the efficacy and safety of calcium and vitamin D supplementation for bone health, particularly in preventing and managing osteoporosis. Ongoing research continues to refine dosage recommendations and explore broader health benefits.
Lab Monitoring
- Serum calcium levels (especially in patients at risk of hypercalcemia or with renal impairment)
- Serum phosphate levels
- Urinary calcium excretion
- Serum 25-hydroxyvitamin D levels (if deficiency is suspected or being monitored)
- Renal function (creatinine, GFR) in patients with kidney issues
Doctor Notes
- Educate patients on the importance of adherence, especially in chronic conditions like osteoporosis.
- Advise patients about potential drug and food interactions, emphasizing separation times for certain medications.
- Counsel on lifestyle modifications including diet, exercise, and sun exposure.
- Monitor serum calcium, vitamin D, and renal function in at-risk patients or those on long-term therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor or as directed on the label.
- Do not exceed the recommended dose without consulting your physician.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Maintain adequate fluid intake to prevent kidney stone formation.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Calcin-D is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Incorporate a calcium-rich diet (dairy products, leafy greens, fortified foods).
- Engage in regular weight-bearing exercise to support bone health.
- Ensure adequate sun exposure for natural Vitamin D synthesis, safely.
- Avoid smoking and excessive alcohol consumption, which can negatively impact bone density.
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