Administered via subcutaneous (SC) or intramuscular (IM) injection. For hypercalcemia, it can also be given intravenously in some cases, but SC/IM is more common. Patients should be taught proper self-injection techniques if administered at home.

Calcitonin acts directly on osteoclasts (cells responsible for bone resorption) by binding to specific receptors, inhibiting their activity. This leads to decreased bone breakdown and subsequent reduction in calcium release from bones into the bloodstream. It also increases renal excretion of calcium and phosphate.

• •Hypersensitivity to calcitonin salmon or any component of the formulation
• •Hypocalcemia

Unopened vials: Store in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Once opened: Store at room temperature (15°C to 30°C / 59°F to 86°F) for up to 28 days.

Symptoms of overdose may include severe hypocalcemia with tetany and possibly nausea and vomiting. Management involves symptomatic and supportive care, including intravenous calcium if hypocalcemia is severe.

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether calcitonin is excreted in human milk; caution should be exercised when administered to a nursing woman.