Calbor-D, Calbon-D, Osvita-D
Generic Name
Calcium Carbonate 1250 mg (equivalent to 500 mg elemental Calcium) with Vitamin D3 200 IU Tablet
Manufacturer
Various (Generic)
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| calcium d 500 mg tablet | ৳ 7.00 | N/A |
Description
Overview of the medicine
Calcium and Vitamin D3 tablets are used to supplement dietary intake of calcium and vitamin D, crucial for maintaining strong bones and teeth, and preventing conditions like osteoporosis, rickets, and osteomalacia.
Uses & Indications
Dosage
Adults
Typically 1-2 tablets daily, or as directed by a physician. Tablets can be taken with or without food.
Elderly
Same as adult dosage, but caution is advised in those with renal impairment or predisposition to hypercalcemia. Monitor serum calcium and Vitamin D levels.
Renal_impairment
Use with caution and monitor serum calcium and phosphate levels closely. Dosage adjustment may be necessary or contraindicated in severe cases. Consult a physician.
How to Take
Take the tablet orally, with or without food. If it's a chewable tablet, chew it thoroughly before swallowing. For film-coated tablets, swallow whole with water. Avoid lying down for at least 10 minutes after taking.
Mechanism of Action
Calcium is an essential mineral for bone formation and maintenance, nerve transmission, muscle contraction, and many other bodily functions. Vitamin D3 (Cholecalciferol) facilitates the absorption of calcium from the gastrointestinal tract and its incorporation into bone, helping to maintain proper calcium and phosphate levels in the body.
Pharmacokinetics
Onset
Therapeutic effects are long-term, typically observed after weeks to months of consistent use for bone health.
Excretion
Calcium is primarily excreted via feces (unabsorbed) and urine (filtered). Vitamin D3 metabolites are primarily excreted in bile and feces, with a small amount excreted renally.
Half life
Elemental calcium has a relatively short half-life in the bloodstream, but is constantly exchanged with bone stores. Vitamin D3 (cholecalciferol) has a half-life of about 24 hours, but its active metabolite, calcitriol, has a half-life of 3-6 hours.
Absorption
Calcium carbonate is absorbed in the small intestine, primarily via active transport and passive diffusion. Vitamin D3 is absorbed from the gastrointestinal tract, especially in the presence of bile salts and dietary fat.
Metabolism
Calcium is not metabolized in the traditional sense, but is dynamically exchanged. Vitamin D3 is hydroxylated in the liver to 25-hydroxyvitamin D (calcifediol), then further hydroxylated in the kidneys to the active form, 1,25-dihydroxyvitamin D (calcitriol).
Side Effects
Contraindications
- •Hypercalcemia (high calcium levels in blood)
- •Hypercalciuria (high calcium levels in urine)
- •Hypervitaminosis D (excess Vitamin D levels)
- •Severe renal impairment
- •Kidney stones (nephrolithiasis)
- •Known hypersensitivity to calcium, Vitamin D, or any excipients
Drug Interactions
Levothyroxine
Calcium can reduce absorption; take at least 4 hours apart.
Bisphosphonates
Calcium can reduce absorption; take at least 30 minutes apart.
Thiazide Diuretics
May increase risk of hypercalcemia.
Digitalis Glycosides
Risk of arrhythmias in hypercalcemia.
Phenytoin, Barbiturates
May increase Vitamin D metabolism and reduce its effects.
Iron and Zinc Supplements
Absorption may be affected; take at least 2 hours apart.
Tetracycline and Quinolone Antibiotics
Calcium can reduce absorption; take at least 2-4 hours apart.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypercalcemia) include nausea, vomiting, constipation, abdominal pain, muscle weakness, fatigue, polydipsia, polyuria, and in severe cases, cardiac arrhythmias, renal impairment, and coma. Management involves discontinuing the supplement, hydration, and medical supervision.
Pregnancy & Lactation
Calcium and Vitamin D are essential during pregnancy and lactation. However, dosage should be carefully monitored to avoid hypercalcemia, which can be harmful to the fetus. Consult a doctor or healthcare provider before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2-3 years from the date of manufacture.
Availability
Pharmacies, drugstores, supermarkets.
Approval Status
Widely approved and available over-the-counter in many countries.
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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