Calpo-D
Generic Name
Paracetamol (Acetaminophen) + Cholecalciferol (Vitamin D3)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| calpo d 500 mg tablet | ৳ 3.67 | N/A |
Description
Overview of the medicine
Calpo-D 500 mg tablet is a combination medicine containing Paracetamol and Cholecalciferol (Vitamin D3). Paracetamol acts as an analgesic and antipyretic, while Cholecalciferol helps in calcium absorption and bone health.
Uses & Indications
Dosage
Adults
1-2 tablets (Paracetamol 500-1000 mg, Cholecalciferol 400-800 IU) every 4-6 hours as needed, not exceeding 8 tablets (4000 mg Paracetamol) in 24 hours, or as directed by a physician.
Elderly
Similar to adults, but caution should be exercised in patients with impaired renal or hepatic function. Dosage adjustment may be necessary.
Renal_impairment
Use with caution. Dosage interval may need to be extended. Consult a physician.
How to Take
For oral administration. Can be taken with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Paracetamol inhibits prostaglandin synthesis primarily in the central nervous system, thereby exerting analgesic and antipyretic effects. Cholecalciferol (Vitamin D3) is converted into active metabolites that regulate calcium and phosphate homeostasis, promoting their absorption from the gut and deposition in bones.
Pharmacokinetics
Onset
Paracetamol: Analgesic effect typically begins within 30-60 minutes. Antipyretic effect within 30 minutes. Cholecalciferol: Long-term effects for bone health, acute effects not applicable.
Excretion
Paracetamol: Excreted predominantly in the urine as glucuronide and sulfate conjugates. Cholecalciferol: Excreted via bile and urine.
Half life
Paracetamol: Approximately 1-4 hours. Cholecalciferol: Parent compound has a half-life of 15-30 hours, while active metabolite (calcitriol) has a half-life of 4-6 hours.
Absorption
Paracetamol: Rapidly and almost completely absorbed from the gastrointestinal tract. Cholecalciferol: Absorbed from the small intestine, requiring bile salts for optimal absorption.
Metabolism
Paracetamol: Primarily metabolized in the liver via glucuronidation and sulfation. Cholecalciferol: Metabolized in the liver to 25-hydroxyvitamin D [25(OH)D] and then in the kidneys to the active form 1,25-dihydroxyvitamin D [1,25(OH)2D].
Side Effects
Contraindications
- Hypersensitivity to paracetamol, cholecalciferol, or any other component of the tablet
- Severe hepatic impairment
- Severe renal impairment
- Hypercalcemia or hypercalciuria
- Known Vitamin D toxicity
Drug Interactions
Warfarin
Concurrent use of paracetamol with warfarin may increase the anticoagulant effect and risk of bleeding.
Cholestyramine
May reduce the absorption of paracetamol and Vitamin D.
Corticosteroids
May reduce the effects of Vitamin D.
Thiazide Diuretics
May increase the risk of hypercalcemia when co-administered with Vitamin D.
Phenobarbital, Carbamazepine, Phenytoin
May increase the hepatotoxicity of paracetamol due to enzyme induction.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Paracetamol overdose can cause severe liver damage, potentially fatal. Symptoms include nausea, vomiting, abdominal pain, and liver tenderness. Cholecalciferol overdose can lead to hypercalcemia, symptoms include nausea, vomiting, polyuria, polydipsia, and weakness. Seek immediate medical attention in case of suspected overdose.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and under strict medical supervision. Paracetamol is generally considered safe in recommended doses, but high doses of Vitamin D should be avoided. Consult your doctor before use.
Side Effects
Contraindications
- Hypersensitivity to paracetamol, cholecalciferol, or any other component of the tablet
- Severe hepatic impairment
- Severe renal impairment
- Hypercalcemia or hypercalciuria
- Known Vitamin D toxicity
Drug Interactions
Warfarin
Concurrent use of paracetamol with warfarin may increase the anticoagulant effect and risk of bleeding.
Cholestyramine
May reduce the absorption of paracetamol and Vitamin D.
Corticosteroids
May reduce the effects of Vitamin D.
Thiazide Diuretics
May increase the risk of hypercalcemia when co-administered with Vitamin D.
Phenobarbital, Carbamazepine, Phenytoin
May increase the hepatotoxicity of paracetamol due to enzyme induction.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Paracetamol overdose can cause severe liver damage, potentially fatal. Symptoms include nausea, vomiting, abdominal pain, and liver tenderness. Cholecalciferol overdose can lead to hypercalcemia, symptoms include nausea, vomiting, polyuria, polydipsia, and weakness. Seek immediate medical attention in case of suspected overdose.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and under strict medical supervision. Paracetamol is generally considered safe in recommended doses, but high doses of Vitamin D should be avoided. Consult your doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on manufacturer specifications.
Availability
Pharmacies, drugstores
Approval Status
Generally approved and widely available
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Both paracetamol and cholecalciferol are well-established active pharmaceutical ingredients with extensive clinical trial data supporting their efficacy and safety profiles individually. Specific trials for this exact combination are not always published as it's a common over-the-counter formulation.
Lab Monitoring
- Liver function tests (especially with prolonged use or high doses of paracetamol)
- Serum calcium and phosphate levels (for Vitamin D supplementation)
- Renal function tests
Doctor Notes
- Advise patients on the maximum daily dose of paracetamol and to avoid concurrent use of other paracetamol-containing products to prevent overdose.
- Consider baseline and periodic liver function tests for patients on prolonged high-dose paracetamol.
- Assess for potential drug interactions, especially with anticoagulants and other enzyme-inducing drugs.
- Educate patients on symptoms of hypercalcemia and the importance of not exceeding recommended Vitamin D intake.
Patient Guidelines
- Do not exceed the recommended dose of paracetamol as it can cause serious liver damage.
- Inform your doctor or pharmacist about all other medications you are taking, especially other paracetamol-containing products or vitamin D supplements.
- If symptoms persist or worsen after a few days, consult a healthcare professional.
- Keep this medicine out of the sight and reach of children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Calpo-D 500 mg tablet is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or any other side effect that may impair your concentration, avoid these activities.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D for optimal bone health.
- Engage in regular weight-bearing exercise to support bone density.
- Avoid excessive alcohol consumption while taking this medication.
- Ensure adequate sunlight exposure for natural Vitamin D synthesis, if appropriate.
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Global Brand Names
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