Adults

One tablet (Cefixime 200 mg + Ofloxacin 200 mg) orally twice daily for 7-14 days, or as directed by the physician. Duration depends on the infection type and severity.

Elderly

Dose adjustment may be necessary in elderly patients with significant renal impairment. Otherwise, no specific dosage adjustment is required based on age alone.

Renal_impairment

Dosage adjustment is necessary. For creatinine clearance 20-49 mL/min, reduce dosage by 50%. For creatinine clearance <20 mL/min, a significant dose reduction or increased dosing interval is required. Consult physician.

Onset

Typically within 1-2 hours for antibacterial action.

Excretion

Cefixime is primarily excreted renally (20-30% unchanged in urine) and partially through bile. Ofloxacin is predominantly excreted renally (70-80% unchanged in urine).

Half life

Cefixime: 3-4 hours; Ofloxacin: 5-8 hours.

Absorption

Both Cefixime and Ofloxacin are well absorbed orally. Cefixime bioavailability is 40-50%, while Ofloxacin bioavailability is ~90-100%.

Metabolism

Cefixime is not significantly metabolized in the liver; Ofloxacin undergoes limited hepatic metabolism (5-10%).

NSAIDs

Concomitant use with NSAIDs may increase the risk of CNS stimulation and convulsive seizures with fluoroquinolones.

Warfarin

May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Monitor INR closely.

Theophylline

Ofloxacin may increase theophylline levels, increasing the risk of toxicity. Monitor theophylline levels.

Antacids/Iron/Multivitamins

Calcium, magnesium, aluminum, iron, and zinc-containing antacids or supplements can significantly reduce Ofloxacin absorption. Administer at least 2 hours before or 6 hours after these agents.