Caphadex
Generic Name
Caphaler
Manufacturer
Medinova Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Caphaler is a first-generation cephalosporin antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
250 mg to 1 g every 6-12 hours, depending on the severity of infection.
Elderly
Same as adults, but dose adjustment may be needed for renal impairment.
Renal_impairment
Dosage reduction is required; consult a physician for specific guidelines.
How to Take
Can be taken with or without food. Complete the full course of treatment.
Mechanism of Action
It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly through renal excretion (glomerular filtration and tubular secretion).
Half life
Approximately 0.5 to 1.2 hours
Absorption
Rapid and almost complete absorption from the gastrointestinal tract.
Metabolism
Minimal metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cephalosporins or penicillins
- Severe renal impairment (without dose adjustment)
Drug Interactions
Metformin
May increase Metformin levels, requiring dose adjustment.
Probenecid
Increases Caphaler levels.
Oral anticoagulants
May increase INR in some patients.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, diarrhea, and hematuria. Management involves symptomatic and supportive care. Hemodialysis may be beneficial.
Pregnancy & Lactation
Generally considered safe during pregnancy (Category B). Small amounts pass into breast milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to cephalosporins or penicillins
- Severe renal impairment (without dose adjustment)
Drug Interactions
Metformin
May increase Metformin levels, requiring dose adjustment.
Probenecid
Increases Caphaler levels.
Oral anticoagulants
May increase INR in some patients.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, diarrhea, and hematuria. Management involves symptomatic and supportive care. Hemodialysis may be beneficial.
Pregnancy & Lactation
Generally considered safe during pregnancy (Category B). Small amounts pass into breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of first-generation cephalosporins for various infections.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- Complete blood count (CBC)
Doctor Notes
- Advise patients to complete the full course of therapy to prevent resistance.
- Monitor renal function in elderly patients or those with pre-existing kidney conditions.
Patient Guidelines
- Take the medicine exactly as prescribed.
- Do not skip doses or stop taking the medicine early, even if you feel better.
- Inform your doctor about any allergies or other medications you are taking.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Driving Precautions
Generally, it does not impair driving ability. However, if you experience dizziness or fatigue, avoid driving.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids.
- Avoid alcohol during treatment as it may exacerbate side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.