Cardofix
Generic Name
Bisoprolol Fumarate
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cardofix 25 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Cardofix (Bisoprolol Fumarate) is a beta-blocker medication primarily used to treat high blood pressure (hypertension), angina (chest pain), and chronic heart failure. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure.
Uses & Indications
Dosage
Adults
Hypertension/Angina: Initially 5 mg once daily, may be increased to 10 mg once daily. Maximum 20 mg/day. Chronic Heart Failure: Initially 1.25 mg once daily, titrated gradually over weeks to a maximum of 10 mg once daily.
Elderly
No specific dose adjustment is usually required unless severe renal or hepatic impairment is present. Start with a lower dose.
Renal_impairment
For severe renal impairment (creatinine clearance <20 mL/min), maximum dose is 10 mg/day. Use with caution.
How to Take
Take orally once daily, preferably in the morning with or without food.
Mechanism of Action
Bisoprolol is a highly cardioselective beta-1 adrenergic receptor blocking agent. It selectively blocks beta-1 receptors in the heart, leading to decreased heart rate, reduced myocardial contractility, and lower blood pressure. It has minimal effect on beta-2 receptors in the lungs and peripheral blood vessels at therapeutic doses.
Pharmacokinetics
Onset
Within 2-4 hours.
Excretion
Approximately 50% excreted unchanged by the kidneys, and the rest as inactive metabolites.
Half life
Approximately 9-12 hours.
Absorption
Well absorbed from the gastrointestinal tract, with bioavailability of about 80%.
Metabolism
Approximately 50% metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Acute heart failure or decompensated heart failure requiring intravenous inotropic therapy
- Cardiogenic shock
- Second or third degree AV block (without a pacemaker)
- Sick sinus syndrome
- Severe bradycardia (<60 bpm prior to therapy)
- Severe hypotension
- Severe asthma or severe chronic obstructive pulmonary disease (COPD)
- Late stages of peripheral arterial occlusive disease and Raynaud's syndrome
- Untreated pheochromocytoma
- Metabolic acidosis
- Hypersensitivity to Bisoprolol or any component of the formulation
Drug Interactions
NSAIDs
May reduce the hypotensive effect of Bisoprolol.
Clonidine
Risk of rebound hypertension upon discontinuation of clonidine if Bisoprolol is not gradually withdrawn first.
Insulin and oral antidiabetics
May mask symptoms of hypoglycemia.
Antiarrhythmics (e.g., amiodarone)
Increased risk of cardiac depression and bradycardia.
Calcium channel blockers (e.g., verapamil, diltiazem)
Increased risk of bradycardia, AV block, and heart failure.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include bradycardia, hypotension, bronchospasm, acute cardiac insufficiency. Management involves supportive care: atropine for bradycardia, vasopressors for hypotension, bronchodilators for bronchospasm, diuretics for cardiac insufficiency.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Small amounts excreted in breast milk; avoid use during lactation or monitor infant for beta-blockade symptoms.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, check product packaging for exact details.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for hypertension, angina, and chronic heart failure, demonstrating significant efficacy and safety profiles.
Lab Monitoring
- Blood pressure
- Heart rate
- Renal function (creatinine, BUN)
- Liver function tests (LFTs) periodically
Doctor Notes
- Always assess patient's cardiac function and comorbidities before initiating and during therapy with Bisoprolol.
- Educate patients on the importance of gradual withdrawal and symptoms of potential adverse effects, especially in patients with ischemic heart disease.
- Monitor blood pressure and heart rate regularly.
Patient Guidelines
- Do not stop taking this medicine abruptly, as it may worsen your condition. Consult your doctor for gradual dose reduction.
- Report any symptoms like extreme tiredness, shortness of breath, or swelling in your ankles to your doctor immediately.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or fatigue, especially at the start of treatment. Avoid driving or operating machinery until you know how you react to the medication.
Lifestyle Advice
- Maintain a healthy diet, low in sodium and saturated fats.
- Regular exercise, as advised by your doctor, can help manage blood pressure and heart health.
- Avoid smoking and limit alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.