Cardoplus
Generic Name
Metoprolol Tartrate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cardoplus 50 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Metoprolol Tartrate is a beta-1 selective adrenergic receptor blocker used to treat hypertension, angina pectoris, and certain cardiac arrhythmias. It reduces heart rate and blood pressure.
Uses & Indications
Dosage
Adults
Typical initial dose for hypertension is 50-100 mg once daily or in divided doses. Max 400 mg/day.
Elderly
Similar to adults, but starting with lower doses may be considered due to potential reduced elimination and increased sensitivity.
Renal_impairment
No dose adjustment is usually required for renal impairment, but caution is advised in severe cases.
How to Take
Take orally with or immediately after food, at the same time each day. Swallow whole; do not crush or chew.
Mechanism of Action
Selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, cardiac output, and blood pressure. It also inhibits renin release.
Pharmacokinetics
Onset
Oral: 1 hour for blood pressure reduction. IV: Minutes.
Excretion
Mainly renal, with about 95% excreted in urine as metabolites, and only a small fraction as unchanged drug.
Half life
3-7 hours.
Absorption
Rapid and complete, but significant first-pass metabolism reduces bioavailability to about 50%. Peak plasma concentrations within 1-2 hours.
Metabolism
Primarily hepatic via CYP2D6.
Side Effects
Contraindications
- Severe bradycardia
- Second- or third-degree heart block
- Cardiogenic shock
- Decompensated heart failure
- Sick sinus syndrome (unless pacemaker in place)
- Severe peripheral arterial disease
Drug Interactions
NSAIDs
May reduce antihypertensive effects.
Digoxin
Additive bradycardia effect.
Clonidine
Risk of rebound hypertension upon clonidine withdrawal.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include bradycardia, hypotension, bronchospasm, cardiac failure, hypoglycemia. Treatment is symptomatic and supportive, may include atropine, glucagon, IV fluids, vasopressors, bronchodilators.
Pregnancy & Lactation
Use in pregnancy only if potential benefit outweighs risk. Excreted in breast milk, use with caution or consider alternatives; monitor infant for beta-blockade effects.
Side Effects
Contraindications
- Severe bradycardia
- Second- or third-degree heart block
- Cardiogenic shock
- Decompensated heart failure
- Sick sinus syndrome (unless pacemaker in place)
- Severe peripheral arterial disease
Drug Interactions
NSAIDs
May reduce antihypertensive effects.
Digoxin
Additive bradycardia effect.
Clonidine
Risk of rebound hypertension upon clonidine withdrawal.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include bradycardia, hypotension, bronchospasm, cardiac failure, hypoglycemia. Treatment is symptomatic and supportive, may include atropine, glucagon, IV fluids, vasopressors, bronchodilators.
Pregnancy & Lactation
Use in pregnancy only if potential benefit outweighs risk. Excreted in breast milk, use with caution or consider alternatives; monitor infant for beta-blockade effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy in hypertension and angina, and reduced mortality in post-MI patients. Ongoing studies explore its use in other cardiovascular conditions.
Lab Monitoring
- Blood pressure
- Heart rate
- Renal function (in patients with impairment)
- Blood glucose (in diabetics)
- Liver function (periodically)
Doctor Notes
- Monitor heart rate and blood pressure closely at initiation and dose adjustments.
- Educate patients on the importance of gradual withdrawal to avoid rebound effects.
- Use with caution in patients with asthma/COPD due to potential for bronchospasm, though cardioselective.
- Consider for patients post-MI and with stable heart failure.
Patient Guidelines
- Do not stop taking abruptly; consult your doctor for gradual dose reduction.
- Report any unusual side effects to your doctor immediately.
- Monitor your blood pressure and heart rate regularly at home.
- Take with food to enhance absorption and reduce GI upset.
- Avoid driving or operating heavy machinery until you know how the medicine affects you.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Driving Precautions
May cause dizziness, fatigue, or blurred vision, especially at the start of treatment or after dose changes. Use caution when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and limit alcohol intake.
- Manage stress effectively through relaxation techniques.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.