Cardoplus
Generic Name
Metoprolol Tartrate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cardoplus 50 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Metoprolol Tartrate is a beta-1 selective adrenergic receptor blocker used to treat hypertension, angina pectoris, and certain cardiac arrhythmias. It reduces heart rate and blood pressure.
Uses & Indications
Dosage
Adults
Typical initial dose for hypertension is 50-100 mg once daily or in divided doses. Max 400 mg/day.
Elderly
Similar to adults, but starting with lower doses may be considered due to potential reduced elimination and increased sensitivity.
Renal_impairment
No dose adjustment is usually required for renal impairment, but caution is advised in severe cases.
How to Take
Take orally with or immediately after food, at the same time each day. Swallow whole; do not crush or chew.
Mechanism of Action
Selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, cardiac output, and blood pressure. It also inhibits renin release.
Pharmacokinetics
Onset
Oral: 1 hour for blood pressure reduction. IV: Minutes.
Excretion
Mainly renal, with about 95% excreted in urine as metabolites, and only a small fraction as unchanged drug.
Half life
3-7 hours.
Absorption
Rapid and complete, but significant first-pass metabolism reduces bioavailability to about 50%. Peak plasma concentrations within 1-2 hours.
Metabolism
Primarily hepatic via CYP2D6.
Side Effects
Contraindications
- •Severe bradycardia
- •Second- or third-degree heart block
- •Cardiogenic shock
- •Decompensated heart failure
- •Sick sinus syndrome (unless pacemaker in place)
- •Severe peripheral arterial disease
Drug Interactions
NSAIDs
May reduce antihypertensive effects.
Digoxin
Additive bradycardia effect.
Clonidine
Risk of rebound hypertension upon clonidine withdrawal.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include bradycardia, hypotension, bronchospasm, cardiac failure, hypoglycemia. Treatment is symptomatic and supportive, may include atropine, glucagon, IV fluids, vasopressors, bronchodilators.
Pregnancy & Lactation
Use in pregnancy only if potential benefit outweighs risk. Excreted in breast milk, use with caution or consider alternatives; monitor infant for beta-blockade effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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