Caripran
Generic Name
Cariprazine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| caripran 15 mg capsule | ৳ 13.00 | ৳ 78.00 |
Description
Overview of the medicine
Cariprazine is an atypical antipsychotic medication primarily used to treat schizophrenia and bipolar I disorder. It helps manage symptoms by modulating certain neurotransmitter activities in the brain.
Uses & Indications
Dosage
Adults
For Schizophrenia: Initial 1.5 mg once daily, target 1.5-6 mg once daily. For Bipolar Mania: Initial 1.5 mg once daily, target 3-6 mg once daily. For Adjunctive MDD: Initial 1.5 mg once daily, target 1.5-3 mg once daily.
Elderly
Use with caution in elderly patients; lower starting doses may be appropriate.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Take orally once daily, with or without food. It is recommended to take the capsule at approximately the same time each day.
Mechanism of Action
Cariprazine acts as a partial agonist at dopamine D3 and D2 receptors, and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptors. This unique receptor binding profile contributes to its therapeutic effects.
Pharmacokinetics
Onset
Therapeutic effects may begin within a few weeks of treatment initiation.
Excretion
Excreted primarily through feces and urine.
Half life
Cariprazine has a half-life of 20-49 hours; its active metabolite, desmethylcariprazine, has a half-life of 1-3 weeks.
Absorption
Well absorbed after oral administration; peak plasma concentrations reached in approximately 4-6 hours.
Metabolism
Primarily metabolized in the liver by CYP3A4 and to a lesser extent by CYP2D6 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Cariprazine or any component of the formulation
Drug Interactions
Strong CYP3A4 Inducers (e.g., rifampin)
May decrease cariprazine plasma concentrations, reducing efficacy.
Strong CYP3A4 Inhibitors (e.g., ketoconazole)
May increase cariprazine plasma concentrations.
Storage
Store below 25°C in a dry and cool place. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive treatment and symptomatic measures should be initiated. Cardiovascular monitoring and respiratory support may be necessary.
Pregnancy & Lactation
Safety during pregnancy has not been established. Use with caution during lactation; consult a doctor. Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms.
Side Effects
Contraindications
- Hypersensitivity to Cariprazine or any component of the formulation
Drug Interactions
Strong CYP3A4 Inducers (e.g., rifampin)
May decrease cariprazine plasma concentrations, reducing efficacy.
Strong CYP3A4 Inhibitors (e.g., ketoconazole)
May increase cariprazine plasma concentrations.
Storage
Store below 25°C in a dry and cool place. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive treatment and symptomatic measures should be initiated. Cardiovascular monitoring and respiratory support may be necessary.
Pregnancy & Lactation
Safety during pregnancy has not been established. Use with caution during lactation; consult a doctor. Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
As indicated on the packaging.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Patented
Clinical Trials
The efficacy and safety of cariprazine have been established through extensive clinical trials.
Lab Monitoring
- Blood glucose levels
- Lipid profile
- Weight
- Blood pressure
Doctor Notes
- Monitor patients closely at treatment initiation and with each dose adjustment.
- Regular monitoring is crucial for patients with pre-existing diabetes or cardiovascular risk factors.
Patient Guidelines
- Do not change the dose or stop the medication without consulting your doctor.
- Be cautious of dizziness or drowsiness, especially when starting treatment.
- Avoid alcohol consumption while taking this medicine.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
This medication may cause drowsiness or dizziness. Exercise caution when driving or operating hazardous machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Practice stress-reduction techniques.
- Ensure adequate hydration.
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Global Brand Names
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