Carlina
Generic Name
Carlina
Manufacturer
PharmaGenetics Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| carlina 5 mg tablet | ৳ 22.00 | ৳ 220.00 |
Description
Overview of the medicine
Carlina 5 mg tablet is an antihypertensive medication primarily used to manage high blood pressure. It belongs to the class of beta-adrenergic blockers, which work by relaxing blood vessels and slowing heart rate to improve blood flow.
Uses & Indications
Dosage
Adults
Initial dose 5 mg once daily, may be increased to 10 mg once daily after 1-2 weeks if necessary. Maximum dose is 20 mg once daily.
Elderly
No specific dose adjustment required, but start with the lowest effective dose (5 mg once daily) and monitor closely.
Renal_impairment
For creatinine clearance <30 mL/min, maximum dose should not exceed 10 mg once daily.
How to Take
Carlina 5 mg tablets should be swallowed whole with water, preferably in the morning before breakfast. Do not chew or crush the tablet.
Mechanism of Action
Carlina selectively blocks beta-1 adrenergic receptors, primarily located in the heart. This blockade reduces heart rate, myocardial contractility, and cardiac output, leading to a decrease in blood pressure. It also inhibits the release of renin from the kidneys, further contributing to its antihypertensive effects.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Mainly renal, with some excretion in feces
Half life
Approximately 8-10 hours
Absorption
Rapidly and completely absorbed from the gastrointestinal tract; bioavailability is approximately 80-90%.
Metabolism
Primarily hepatic, extensive first-pass metabolism
Side Effects
Contraindications
- Severe bradycardia (<50 beats/min)
- Cardiogenic shock
- Uncontrolled heart failure
- Second or third-degree atrioventricular block
- Sick sinus syndrome
Drug Interactions
Digoxin
Increased risk of bradycardia.
NSAIDs (e.g., Ibuprofen, Indomethacin)
May reduce the antihypertensive effect of Carlina.
Antidiabetic drugs (e.g., Insulin, Sulfonylureas)
Carlina may mask symptoms of hypoglycemia and potentiate hypoglycemic effects.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and hypotension. Avoid concomitant use.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, acute heart failure, and bronchospasm. Management involves symptomatic and supportive measures. Atropine, vasopressors, glucagon, and cardiac pacing may be necessary.
Pregnancy & Lactation
Pregnancy Category C. Carlina should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; therefore, caution should be exercised when Carlina is administered to a nursing woman.
Side Effects
Contraindications
- Severe bradycardia (<50 beats/min)
- Cardiogenic shock
- Uncontrolled heart failure
- Second or third-degree atrioventricular block
- Sick sinus syndrome
Drug Interactions
Digoxin
Increased risk of bradycardia.
NSAIDs (e.g., Ibuprofen, Indomethacin)
May reduce the antihypertensive effect of Carlina.
Antidiabetic drugs (e.g., Insulin, Sulfonylureas)
Carlina may mask symptoms of hypoglycemia and potentiate hypoglycemic effects.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and hypotension. Avoid concomitant use.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, acute heart failure, and bronchospasm. Management involves symptomatic and supportive measures. Atropine, vasopressors, glucagon, and cardiac pacing may be necessary.
Pregnancy & Lactation
Pregnancy Category C. Carlina should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; therefore, caution should be exercised when Carlina is administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Pending
Clinical Trials
Carlina has undergone extensive Phase I, II, and III clinical trials demonstrating its efficacy and safety profile for the management of hypertension and angina pectoris.
Lab Monitoring
- Blood pressure monitoring
- Heart rate monitoring
- Renal function tests (e.g., creatinine, BUN)
- Blood glucose (in diabetic patients)
Doctor Notes
- Emphasize gradual withdrawal to avoid rebound effects.
- Monitor for signs of heart failure exacerbation.
- Caution in patients with asthma or COPD due to potential bronchospasm.
Patient Guidelines
- Do not stop taking Carlina abruptly without consulting your doctor.
- Take the tablet at the same time each day.
- Report any unusual side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Carlina may cause dizziness or fatigue. Patients should be cautioned about engaging in activities requiring mental alertness, such as driving or operating machinery, until they know how the drug affects them.
Lifestyle Advice
- Adopt a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity.
- Limit alcohol intake and avoid smoking.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.