Carlos
Generic Name
Losartan Potassium
Manufacturer
Hypothetical Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| carlos 50 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Carlos 50 mg Tablet is an Angiotensin II Receptor Blocker (ARB) used to treat high blood pressure (hypertension) and to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. It is also used to treat kidney disease in patients with type 2 diabetes and a history of hypertension.
Uses & Indications
Dosage
Adults
Initial dose 50 mg once daily, maximum dose 100 mg once daily. Dosage adjusted based on blood pressure response.
Elderly
No initial dosage adjustment generally required, but close monitoring is advised.
Renal_impairment
No initial dosage adjustment required for mild to moderate renal impairment. For severe impairment (CrCl <30 mL/min), a lower starting dose (e.g., 25 mg) may be considered.
How to Take
Take orally with or without food, usually once daily. It is best to take it at the same time each day.
Mechanism of Action
Losartan selectively blocks the binding of angiotensin II to the AT1 receptor, which is found in many tissues, including vascular smooth muscle and the adrenal gland. This blockade inhibits the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation, decreased blood pressure, and reduced sodium and water retention.
Pharmacokinetics
Onset
Within 6 hours, maximum effect within 3-6 weeks
Excretion
About 35% excreted in urine and 60% in feces (via bile), mainly as unchanged drug and its active metabolite.
Half life
Losartan: 2 hours; Active metabolite (E-3174): 6-9 hours
Absorption
Well absorbed orally, bioavailability about 33%. Peak plasma concentrations of Losartan are reached in about 1 hour and for its active metabolite (E-3174) in 3-4 hours.
Metabolism
Extensively metabolized by cytochrome P450 enzymes (CYP2C9 and CYP3A4) to an active carboxylic acid metabolite (E-3174) and several inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to Losartan or any component of the formulation
- •Concomitant use with Aliskiren in patients with diabetes
- •Pregnancy (second and third trimesters)
Drug Interactions
Lithium
Increased serum lithium concentrations and lithium toxicity have been reported.
Potassium-sparing diuretics
May lead to increased serum potassium levels.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment, especially in elderly or dehydrated patients.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hypotension and tachycardia; bradycardia could occur. Treatment is supportive, including IV fluids for hypotension. Hemodialysis is unlikely to remove Losartan.
Pregnancy & Lactation
Contraindicated in the second and third trimesters of pregnancy due to fetal toxicity. Not recommended during breastfeeding as it is unknown if Losartan is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, patent expired for Losartan Potassium
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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