Catium
Generic Name
Catium 275 mcg Inhalation Capsule
Manufacturer
Innovate Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| catium 275 mcg inhalation capsule | ৳ 20.00 | ৳ 120.00 |
Description
Overview of the medicine
Catium 275 mcg Inhalation Capsule is a long-acting bronchodilator used for the maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD) and as an add-on maintenance treatment for asthma.
Uses & Indications
Dosage
Adults
The recommended dose is one Catium 275 mcg capsule once daily, inhaled orally using the provided inhaler device. Do not swallow the capsule.
Elderly
No dosage adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with mild to moderate renal impairment. Use with caution in patients with severe renal impairment (creatinine clearance <30 mL/min).
How to Take
Catium capsules are for oral inhalation only and should be used with the specific inhaler device provided. Do not swallow the capsule. Follow the instructions for use provided with the inhaler device carefully. Inhale the contents of one capsule once daily at the same time each day.
Mechanism of Action
Catium acts as a long-acting muscarinic antagonist (LAMA). It selectively binds to M3 muscarinic receptors in the smooth muscles of the airways, inhibiting acetylcholine-induced bronchoconstriction. This results in bronchodilation and improved lung function.
Pharmacokinetics
Onset
Onset of bronchodilation typically occurs within 15-30 minutes after inhalation.
Excretion
Approximately 70% excreted in urine (primarily as metabolites) and 20% in feces, with a small portion excreted unchanged.
Half life
The effective half-life is approximately 24 hours, supporting once-daily dosing.
Absorption
Rapidly absorbed into the systemic circulation after inhalation, but with low systemic bioavailability (approximately 10-15%) due to extensive first-pass metabolism and low gastrointestinal absorption.
Metabolism
Primarily metabolized in the liver by esterases and cytochrome P450 enzymes (e.g., CYP2D6, CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Catium or any excipients of the capsule.
- Not indicated for the rapid relief of acute bronchospasm or for status asthmaticus.
Drug Interactions
Adrenergic drugs
No significant interactions with adrenergic drugs have been reported, but caution is advised with concomitant use of other bronchodilators.
Other anticholinergics
Co-administration with other anticholinergic medications may potentiate anticholinergic effects and should be avoided.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose may lead to exaggerated anticholinergic signs and symptoms such as dry mouth, blurred vision, increased heart rate. Treatment should be supportive and symptomatic. Consult a healthcare professional immediately.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Catium is excreted in human milk. Exercise caution when administered to a nursing mother. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Catium or any excipients of the capsule.
- Not indicated for the rapid relief of acute bronchospasm or for status asthmaticus.
Drug Interactions
Adrenergic drugs
No significant interactions with adrenergic drugs have been reported, but caution is advised with concomitant use of other bronchodilators.
Other anticholinergics
Co-administration with other anticholinergic medications may potentiate anticholinergic effects and should be avoided.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose may lead to exaggerated anticholinergic signs and symptoms such as dry mouth, blurred vision, increased heart rate. Treatment should be supportive and symptomatic. Consult a healthcare professional immediately.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Catium is excreted in human milk. Exercise caution when administered to a nursing mother. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Under patent protection
WHO Essential Medicine
YesClinical Trials
Catium has undergone rigorous Phase III clinical trials demonstrating its efficacy and safety in adult patients with COPD and asthma. Trials have shown significant improvements in FEV1 and reductions in exacerbation rates compared to placebo.
Lab Monitoring
- Routine pulmonary function tests (e.g., FEV1) to monitor efficacy.
- Monitor for signs of anticholinergic side effects.
Doctor Notes
- Emphasize the importance of correct inhalation technique for optimal drug delivery.
- Catium is a maintenance therapy; instruct patients not to use it for acute symptom relief.
- Advise patients to report any significant anticholinergic side effects, particularly urinary retention or blurred vision.
Patient Guidelines
- Use Catium regularly as prescribed, even on symptom-free days.
- Ensure proper inhaler technique as demonstrated by your doctor or pharmacist.
- Catium is for maintenance treatment and not for immediate relief of acute breathing problems.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time to make up for a missed dose.
Driving Precautions
Catium is unlikely to affect the ability to drive or operate machinery. However, if side effects such as dizziness or blurred vision occur, avoid driving or operating machinery.
Lifestyle Advice
- Avoid exposure to respiratory irritants such as smoke, dust, and allergens.
- Maintain a healthy lifestyle, including regular exercise and a balanced diet.
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