Catium-ES
Generic Name
Indacaterol 110 mcg + Glycopyrronium 50 mcg inhalation capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| catium es 110 mcg inhalation capsule | ৳ 50.00 | ৳ 300.00 |
Description
Overview of the medicine
Catium-ES 110 mcg Inhalation Capsule is a combination medicine containing a long-acting beta2-agonist (LABA) and a long-acting muscarinic antagonist (LAMA), used for the maintenance treatment of chronic obstructive pulmonary disease (COPD).
Uses & Indications
Dosage
Adults
One Catium-ES 110 mcg Inhalation Capsule inhaled once daily using an appropriate inhaler device.
Elderly
No dosage adjustment required.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
For oral inhalation only. The capsule should be placed in the dry powder inhaler device, and the contents inhaled. Do not swallow the capsule.
Mechanism of Action
Indacaterol stimulates beta2-adrenergic receptors in the airways, leading to bronchodilation. Glycopyrronium blocks muscarinic receptors in the airways, preventing bronchoconstriction. Together, they relax airway smooth muscles, improving lung function.
Pharmacokinetics
Onset
Within 5 minutes
Excretion
Indacaterol: Primarily fecal, some renal. Glycopyrronium: Primarily renal (unaltered drug), some fecal.
Half life
Indacaterol: 40-56 hours (terminal). Glycopyrronium: 33-57 hours (terminal).
Absorption
Indacaterol: Rapidly absorbed, peak plasma concentration within 15 min. Glycopyrronium: Low systemic absorption, peak plasma concentration within 5-15 min.
Metabolism
Indacaterol: Primarily by UGT1A1 and CYP3A4. Glycopyrronium: Limited metabolism, mainly by CYP2D6.
Side Effects
Contraindications
- Hypersensitivity to indacaterol, glycopyrronium, or any excipients.
- Not for acute bronchospasm.
Drug Interactions
Diuretics
May cause hypokalemia with high doses of LABAs.
Beta-blockers
Can reduce the bronchodilatory effect of indacaterol.
Anticholinergics
Additive effects with other anticholinergic drugs.
CYP3A4/UGT1A1 inhibitors
Can increase indacaterol levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include tachycardia, tremor, headache, and dry mouth. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk. Exercise caution when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to indacaterol, glycopyrronium, or any excipients.
- Not for acute bronchospasm.
Drug Interactions
Diuretics
May cause hypokalemia with high doses of LABAs.
Beta-blockers
Can reduce the bronchodilatory effect of indacaterol.
Anticholinergics
Additive effects with other anticholinergic drugs.
CYP3A4/UGT1A1 inhibitors
Can increase indacaterol levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include tachycardia, tremor, headache, and dry mouth. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk. Exercise caution when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Patented (active ingredient components)
Clinical Trials
Extensive clinical trials (e.g., IGNITE program) demonstrated significant improvements in lung function, dyspnea, and health-related quality of life in COPD patients compared to placebo and monotherapy.
Lab Monitoring
- No routine lab monitoring typically required. Monitor pulmonary function, especially FEV1.
Doctor Notes
- Emphasize proper inhaler technique.
- Advise patients not to use for acute relief.
- Monitor for systemic anticholinergic and beta-agonist side effects.
Patient Guidelines
- Read the patient information leaflet.
- Use the inhaler device correctly.
- Do not stop treatment without consulting your doctor.
- Do not use for acute symptoms.
Missed Dose Advice
If a dose is missed, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not take a double dose.
Driving Precautions
May cause dizziness or blurred vision in some individuals, which could affect the ability to drive or operate machinery. Exercise caution.
Lifestyle Advice
- Avoid smoking.
- Practice breathing exercises as advised.
- Maintain a healthy lifestyle.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.