Cavinton
Generic Name
Vinpocetine
Manufacturer
Gedeon Richter
Country
Hungary
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cavinton 5 mg tablet | ৳ 9.82 | ৳ 245.50 |
Description
Overview of the medicine
Vinpocetine is a synthetic derivative of the Vinca minor alkaloid vincamine. It is used to improve cerebral blood flow and metabolism, and has neuroprotective effects. Cavinton 5 mg tablet is primarily indicated for various neurological conditions related to cerebrovascular insufficiency.
Uses & Indications
Dosage
Adults
Usually 5-10 mg three times daily. The dose can be adjusted based on clinical response and tolerability.
Elderly
No specific dose adjustment is generally required for elderly patients, same as adults.
Renal_impairment
No specific dose adjustment is generally required for mild to moderate renal impairment. Caution is advised in severe renal impairment.
How to Take
Take tablets orally, preferably after meals, to enhance absorption.
Mechanism of Action
Vinpocetine selectively increases cerebral blood flow and metabolism by inhibiting phosphodiesterase type 1 (PDE1), leading to increased cGMP levels in vascular smooth muscle. It also improves red blood cell deformability, reduces blood viscosity, and has antioxidant and neuroprotective properties. It enhances glucose and oxygen utilization in the brain.
Pharmacokinetics
Onset
Clinical effects may take days to weeks to become apparent, depending on the condition being treated.
Excretion
Excreted renally (approximately 60%) and fecally (approximately 40%) as metabolites and unchanged drug.
Half life
Approximately 4.5-5 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 1 hour. Bioavailability is low (approximately 7%) due to extensive first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily by esterases, to form active and inactive metabolites. The main metabolite is apovincaminic acid (AVA).
Side Effects
Contraindications
- Hypersensitivity to Vinpocetine or any components of the formulation.
- Acute cerebral hemorrhage.
- Severe ischemic heart disease or severe arrhythmia.
- Pregnancy and lactation.
- Children.
Drug Interactions
Antihypertensives
May enhance the hypotensive effects of antihypertensive drugs. Blood pressure monitoring is advised.
Antiarrhythmics (e.g., Quinidine)
Caution advised due to potential for additive cardiac effects.
Anticoagulants (e.g., Warfarin, Heparin)
May increase the risk of bleeding. Close monitoring is recommended.
Central Nervous System (CNS) Depressants
Potential for additive sedative effects with other CNS depressants.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include hypotension, gastrointestinal upset, and dizziness. In case of overdose, discontinue the drug and initiate supportive and symptomatic treatment. No specific antidote is available.
Pregnancy & Lactation
Cavinton is contraindicated during pregnancy and lactation due to lack of adequate safety data and potential harm to the fetus/infant. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, refer to the product packaging for exact date.
Availability
Available in pharmacies
Approval Status
Approved in many countries (e.g., EU, Asia)
Patent Status
Off-patent (Generic available)
Clinical Trials
Vinpocetine has been evaluated in numerous clinical trials for its efficacy in improving cognitive function and neurological symptoms in patients with cerebrovascular disorders. Studies often highlight its role in enhancing cerebral blood flow and metabolism.
Lab Monitoring
- Regular blood pressure monitoring, especially in patients also taking antihypertensive medications.
- Liver and renal function tests may be considered in patients with pre-existing conditions or during long-term therapy.
Doctor Notes
- Assess patient's cardiovascular status before initiating therapy.
- Advise patients on potential interactions with anticoagulants and antiarrhythmics.
- Consider liver and renal function in patients with pre-existing impairments during long-term treatment.
Patient Guidelines
- Take Cavinton exactly as prescribed by your doctor.
- Swallow the tablet whole with water, preferably after meals.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cavinton may cause dizziness or lightheadedness in some patients. If you experience these symptoms, avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a healthy lifestyle, including a balanced diet and regular exercise, to support overall cerebrovascular health.
- Avoid smoking and excessive alcohol consumption.
- Monitor your blood pressure regularly as advised by your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.