Cavinton
Generic Name
Vinpocetine
Manufacturer
Gedeon Richter Plc.
Country
Hungary
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cavinton 10 mg injection | ৳ 50.20 | N/A |
Description
Overview of the medicine
Vinpocetine is a synthetic derivative of the Vinca minor alkaloid vincamine, used to treat various cerebrovascular disorders and cognitive impairments. It works by improving cerebral blood flow and neuronal metabolism.
Uses & Indications
Dosage
Adults
Typically 10-20 mg diluted in 500-1000 ml infusion solution (isotonic saline or glucose), administered intravenously over 60-90 minutes, 1-2 times daily. Treatment usually lasts for 10-14 days, followed by oral maintenance therapy.
Elderly
No specific dosage adjustment usually required, but careful monitoring is advisable.
Renal_impairment
No specific dosage adjustment recommended.
How to Take
Administer as an intravenous infusion only, diluted in isotonic saline or glucose solution. Do not administer undiluted or as an intramuscular injection. The infusion rate should not exceed 80 drops/minute.
Mechanism of Action
Vinpocetine acts as a selective cerebral vasodilator, improves cerebral microcirculation, and enhances glucose and oxygen utilization in the brain. It inhibits phosphodiesterase 1 (PDE1), leading to increased cGMP levels, which results in relaxation of cerebral smooth muscles and improved neuronal metabolism. It also has neuroprotective effects.
Pharmacokinetics
Onset
Rapid (within minutes for IV infusion).
Excretion
Mainly renal and fecal.
Half life
Approximately 2-3 hours.
Absorption
Rapidly available after intravenous administration.
Metabolism
Primarily hepatic, metabolized to apovincaminic acid (AVA).
Side Effects
Contraindications
- Known hypersensitivity to vinpocetine or other vinca alkaloids.
- Acute cerebral hemorrhage.
- Severe coronary artery disease.
- Severe arrhythmias.
- Pregnancy and lactation.
Drug Interactions
Antihypertensives
May potentiate hypotensive effects, leading to a drop in blood pressure.
QT-prolonging drugs
Use with caution due to potential additive effects on QT interval.
Anticoagulants/Antiplatelets
May increase the risk of bleeding.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms of overdose may include hypotension and cardiac arrhythmias. Management is symptomatic and supportive, with close monitoring of vital signs and cardiac function.
Pregnancy & Lactation
Contraindicated during pregnancy due to lack of sufficient safety data and potential for fetal harm. Also contraindicated during lactation as vinpocetine is excreted into breast milk.
Side Effects
Contraindications
- Known hypersensitivity to vinpocetine or other vinca alkaloids.
- Acute cerebral hemorrhage.
- Severe coronary artery disease.
- Severe arrhythmias.
- Pregnancy and lactation.
Drug Interactions
Antihypertensives
May potentiate hypotensive effects, leading to a drop in blood pressure.
QT-prolonging drugs
Use with caution due to potential additive effects on QT interval.
Anticoagulants/Antiplatelets
May increase the risk of bleeding.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms of overdose may include hypotension and cardiac arrhythmias. Management is symptomatic and supportive, with close monitoring of vital signs and cardiac function.
Pregnancy & Lactation
Contraindicated during pregnancy due to lack of sufficient safety data and potential for fetal harm. Also contraindicated during lactation as vinpocetine is excreted into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to the manufacturer's specific product labeling.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Vinpocetine has been evaluated in numerous clinical trials demonstrating its efficacy in improving cerebral circulation and cognitive function in patients with cerebrovascular disorders. Ongoing research continues to explore its neuroprotective and anti-inflammatory potentials.
Lab Monitoring
- Regular blood pressure monitoring.
- ECG monitoring, especially in patients with pre-existing cardiac conditions or on QT-prolonging drugs.
Doctor Notes
- Ensure proper dilution of the injection solution before intravenous administration.
- Monitor ECG in patients with pre-existing cardiac conditions or those receiving QT-prolonging agents.
- Contraindicated in acute cerebral hemorrhage; consider alternative treatments.
- Advise patients transitioning from IV to oral therapy on correct dosage and administration.
Patient Guidelines
- This injection is administered by a qualified healthcare professional in a clinical setting.
- Inform your doctor about all your medical conditions, especially heart problems, and all medications you are taking.
- Report any unusual or severe symptoms immediately to your healthcare provider during or after the infusion.
Missed Dose Advice
As Cavinton injection is administered by a healthcare professional, contact your doctor or nurse immediately to reschedule a missed dose.
Driving Precautions
Vinpocetine may cause dizziness or lightheadedness. Patients should be cautious when driving or operating machinery, especially during the initial phase of treatment.
Lifestyle Advice
- Follow your doctor's advice regarding the management of underlying conditions such as hypertension or diabetes.
- Maintain a healthy lifestyle, including a balanced diet and regular exercise, as advised by your healthcare provider.
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