Cazar
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cazar 20 mg capsule | ৳ 870.00 | ৳ 18,270.00 |
Description
Overview of the medicine
Cazar 20 mg Capsule contains Omeprazole, a proton pump inhibitor used to treat conditions caused by excess stomach acid, such as heartburn, acid reflux, ulcers, and Zollinger-Ellison syndrome. It works by decreasing the amount of acid produced in the stomach.
Uses & Indications
Dosage
Adults
Typical dosage for GERD and ulcers is 20 mg once daily for 4-8 weeks. For severe cases or Zollinger-Ellison syndrome, doses may be higher (e.g., 40-60 mg daily or more).
Elderly
No specific dosage adjustment is typically required, but caution is advised in elderly patients with hepatic impairment.
Renal_impairment
No dosage adjustment is necessary for patients with impaired renal function.
How to Take
Usually taken once daily in the morning, preferably before a meal. Swallow the capsule whole with water; do not chew or crush.
Mechanism of Action
Omeprazole is a proton pump inhibitor that irreversibly blocks the H+/K+-ATPase enzyme system (the 'proton pump') in the gastric parietal cells. This inhibition prevents the final step of acid secretion, thereby reducing gastric acid production.
Pharmacokinetics
Onset
Acid secretion inhibition occurs within 1 hour, maximum effect within 2 hours. Full acid suppression may take several days of therapy.
Excretion
Approximately 80% of metabolites are excreted in the urine and approximately 20% in the feces (bile secretion).
Half life
Plasma elimination half-life is approximately 0.5 to 1 hour, but the duration of acid suppression is much longer due to irreversible binding to the proton pump.
Absorption
Rapidly but variably absorbed from the gastrointestinal tract, primarily in the small intestine. Bioavailability is approximately 30-40% but increases with repeated dosing due to reduced first-pass metabolism.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Omeprazole or any component of the formulation
- Concomitant use with Nelfinavir
Drug Interactions
Warfarin
Increased INR/prothrombin time; monitor anticoagulant effects closely.
Clopidogrel
May reduce the antiplatelet effect of Clopidogrel by inhibiting CYP2C19. Consider alternative PPIs or antiplatelet therapy.
Methotrexate
May increase serum levels of methotrexate, particularly high-dose methotrexate; consider temporary PPI withdrawal.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to Omeprazole or any component of the formulation
- Concomitant use with Nelfinavir
Drug Interactions
Warfarin
Increased INR/prothrombin time; monitor anticoagulant effects closely.
Clopidogrel
May reduce the antiplatelet effect of Clopidogrel by inhibiting CYP2C19. Consider alternative PPIs or antiplatelet therapy.
Methotrexate
May increase serum levels of methotrexate, particularly high-dose methotrexate; consider temporary PPI withdrawal.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture, specific to lot.
Availability
Pharmacies, hospitals, clinics
Approval Status
FDA approved (Generic Omeprazole)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Omeprazole has been extensively studied in numerous clinical trials for its efficacy and safety in treating various acid-related disorders.
Lab Monitoring
- Magnesium levels (for long-term use)
- Bone mineral density (for very long-term use in at-risk patients)
Doctor Notes
- Counsel patients on potential long-term side effects such as hypomagnesemia and bone fracture risk, especially in elderly or at-risk individuals.
- Review the need for continued PPI therapy periodically; de-escalation or discontinuation may be appropriate for some patients.
- Be aware of drug interactions, particularly with Clopidogrel and Methotrexate.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; avoid driving or operating machinery if affected.
Lifestyle Advice
- Avoid trigger foods (e.g., spicy, fatty foods, caffeine, carbonated drinks).
- Eat smaller, more frequent meals.
- Elevate the head of your bed to reduce reflux symptoms at night.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.