Ce-Infusor-LV
Generic Name
Ceftriaxone Injection
Manufacturer
Hypothetical Manufacturer (e.g., Square Pharmaceuticals)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ce infusor lv injection | ৳ 3,700.00 | N/A |
Description
Overview of the medicine
Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic used to treat various bacterial infections, including severe and life-threatening ones. It is administered via injection.
Uses & Indications
Dosage
Adults
Usual adult dose is 1-2g once daily, or 0.5-1g every 12 hours, depending on the severity of the infection. Maximum dose is 4g daily.
Elderly
No specific dose adjustment is required for the elderly unless there is severe renal or hepatic impairment.
Renal_impairment
No dose adjustment needed for mild to moderate renal impairment. For severe impairment (creatinine clearance <10 mL/min), dosage should not exceed 2g daily. Dialysis patients may not require supplemental doses.
How to Take
After reconstitution, Ceftriaxone injection can be administered either intravenously (IV) as a slow infusion over 30 minutes or intramuscularly (IM) by deep injection into a large muscle mass. Do not inject more than 1g into a single IM site.
Mechanism of Action
Ceftriaxone works by inhibiting the synthesis of the bacterial cell wall, leading to bacterial lysis and death. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall.
Pharmacokinetics
Onset
Rapid onset of action after IV administration.
Excretion
Dual excretion (approximately 50-60% via renal route and 40-50% via biliary/fecal route).
Half life
Approximately 6-9 hours (longer in neonates and elderly).
Absorption
Rapid and complete absorption after intramuscular (IM) injection; 100% bioavailability for intravenous (IV) administration.
Metabolism
Primarily not metabolized in the liver; about 33-67% is excreted unchanged in the urine, and the remainder is excreted in the bile as active compounds or inactive metabolites formed by gut flora.
Side Effects
Contraindications
- Known hypersensitivity to Ceftriaxone, any other cephalosporin, or to any of the excipients.
- In neonates (≤28 days) with hyperbilirubinemia, especially premature neonates, due to the risk of bilirubin encephalopathy.
- Concomitant use with calcium-containing solutions in neonates (≤28 days).
Drug Interactions
Aminoglycosides
May increase the risk of nephrotoxicity and ototoxicity.
Calcium-containing solutions
Concomitant use is contraindicated in neonates due to precipitation risk. In other age groups, a sequential administration with flushing is recommended.
Loop Diuretics (e.g., Furosemide)
May increase the risk of nephrotoxicity.
Oral Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect, increasing the risk of bleeding.
Storage
Store powder for injection below 30°C, protected from light and moisture. Reconstituted solutions should be used immediately or stored as per manufacturer's guidelines (e.g., for 24 hours at 2-8°C).
Overdose
In case of overdose, the drug concentration would not be reduced by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. It is excreted in breast milk in small quantities, so caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to Ceftriaxone, any other cephalosporin, or to any of the excipients.
- In neonates (≤28 days) with hyperbilirubinemia, especially premature neonates, due to the risk of bilirubin encephalopathy.
- Concomitant use with calcium-containing solutions in neonates (≤28 days).
Drug Interactions
Aminoglycosides
May increase the risk of nephrotoxicity and ototoxicity.
Calcium-containing solutions
Concomitant use is contraindicated in neonates due to precipitation risk. In other age groups, a sequential administration with flushing is recommended.
Loop Diuretics (e.g., Furosemide)
May increase the risk of nephrotoxicity.
Oral Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect, increasing the risk of bleeding.
Storage
Store powder for injection below 30°C, protected from light and moisture. Reconstituted solutions should be used immediately or stored as per manufacturer's guidelines (e.g., for 24 hours at 2-8°C).
Overdose
In case of overdose, the drug concentration would not be reduced by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. It is excreted in breast milk in small quantities, so caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, as specified by the manufacturer on the packaging. Reconstituted solutions have limited stability.
Availability
Hospitals, retail pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Ceftriaxone has undergone extensive clinical trials demonstrating its efficacy and safety across various bacterial infections, leading to its widespread use globally.
Lab Monitoring
- Complete Blood Count (CBC) for prolonged therapy
- Renal function tests (BUN, creatinine)
- Liver function tests (ALT, AST, bilirubin)
Doctor Notes
- Administer IV infusion slowly over 30 minutes to minimize vein irritation.
- Monitor renal and hepatic function, especially in patients with pre-existing impairment or during prolonged therapy.
- Caution with concomitant use of calcium-containing solutions in all age groups, strict contraindication in neonates.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if you feel better.
- Report any unusual or severe side effects to your doctor immediately.
- Do not share this medicine with others, even if they have similar symptoms.
Missed Dose Advice
If a dose of Ce-Infusor-LV is missed, administer it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Ceftriaxone may cause dizziness or lightheadedness in some individuals. Patients should be cautioned about operating machinery or driving until they know how the medication affects them.
Lifestyle Advice
- Maintain good personal hygiene to prevent the spread of infection.
- Stay hydrated by drinking plenty of fluids.
- Follow a balanced diet and get adequate rest to support recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.