Ceeta
Generic Name
Paracetamol
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ceeta 250 mg chewable tablet | ৳ 0.82 | N/A |
Description
Overview of the medicine
Ceeta (Paracetamol) is an analgesic and antipyretic medicine used to relieve pain and reduce fever. It is widely used for mild to moderate pain.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg every 4-6 hours as needed. Maximum 4000 mg in 24 hours.
Elderly
Same as adult dose, but caution in patients with hepatic or renal impairment.
Renal_impairment
Dosage adjustment needed in severe renal impairment (e.g., reduce dose or extend interval).
How to Take
Administer orally with or without food. Can be taken with food to reduce gastric upset, though generally well-tolerated.
Mechanism of Action
Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, thus blocking pain impulse generation. It also acts on the hypothalamic heat-regulating center to produce antipyresis.
Pharmacokinetics
Onset
Pain relief: 30-60 minutes; Fever reduction: within 30 minutes.
Excretion
Mainly excreted in urine as glucuronide and sulfate conjugates, with less than 5% excreted as unchanged drug.
Half life
1-4 hours (typically 2-3 hours).
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes.
Metabolism
Primarily metabolized in the liver, mainly by conjugation with glucuronic acid and sulfate. A small amount is metabolized by cytochrome P450 to a highly reactive intermediate (NAPQI), which is then detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol
- Severe hepatic impairment
Drug Interactions
Alcohol
Increases risk of hepatotoxicity.
Warfarin
May increase anticoagulant effect, requiring INR monitoring.
Phenobarbital, Carbamazepine
May increase risk of hepatotoxicity.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, anorexia. Severe overdose can lead to hepatotoxicity (liver damage). Treatment involves gastric lavage, activated charcoal, and N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to paracetamol
- Severe hepatic impairment
Drug Interactions
Alcohol
Increases risk of hepatotoxicity.
Warfarin
May increase anticoagulant effect, requiring INR monitoring.
Phenobarbital, Carbamazepine
May increase risk of hepatotoxicity.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, anorexia. Severe overdose can lead to hepatotoxicity (liver damage). Treatment involves gastric lavage, activated charcoal, and N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years
Availability
Available in all pharmacies and drug stores
Approval Status
DGDA approved
Patent Status
Generic (Patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established paracetamol's efficacy and safety over decades. Ongoing research focuses on specific populations or formulations.
Lab Monitoring
- Liver function tests (in prolonged use or overdose suspicion)
- Renal function tests (in patients with kidney impairment)
Doctor Notes
- Educate patients on maximum daily dose and avoiding concomitant paracetamol products.
- Counsel on alcohol interaction.
- Consider lower doses in elderly or those with hepatic/renal impairment.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking with other paracetamol-containing products.
- Consult a doctor if symptoms persist for more than a few days.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Paracetamol generally does not impair ability to drive or operate machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Get enough rest.
- Avoid alcohol while taking paracetamol, especially in large doses.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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