Adults

Typically 500 mg to 1 g twice daily, or 1 g once daily for uncomplicated UTIs. For severe infections, up to 2 g daily in divided doses. (Note: 200 mg/5 mL suspension is primarily for pediatric use)

Elderly

Dosage adjustment may be necessary based on renal function. Monitor renal parameters.

Renal_impairment

Initial dose of 500 mg, followed by maintenance doses adjusted based on creatinine clearance (e.g., every 12-24 hours for moderate impairment, every 24-36 hours for severe impairment).

Onset

Within 1-2 hours of oral administration.

Excretion

Primarily excreted unchanged by the kidneys via glomerular filtration and tubular secretion. About 90% of the dose is excreted within 24 hours.

Half life

Approximately 1.5 to 2 hours in adults with normal renal function, prolonged in renal impairment.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract (about 90% bioavailable). Peak plasma concentrations occur 1-2 hours after administration.

Metabolism

Minimally metabolized in the liver; primarily excreted unchanged.

Probenecid

May decrease renal tubular secretion of cefadroxil, leading to increased and prolonged plasma concentrations of cefadroxil.

Loop Diuretics (e.g., Furosemide)

Concomitant use with cephalosporins may increase the risk of nephrotoxicity, especially in patients with pre-existing renal impairment.

Oral Anticoagulants (e.g., Warfarin)

May enhance the anticoagulant effect by altering gut flora and potentially reducing vitamin K synthesis. Monitor INR/PT closely.