Cefazol
Generic Name
Cefazolin 500 mg Injection
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cefazol 500 mg injection | ৳ 125.00 | N/A |
Description
Overview of the medicine
Cefazolin is a first-generation cephalosporin antibiotic used to treat a variety of bacterial infections. It is administered via injection.
Uses & Indications
Dosage
Adults
250 mg to 1 g every 6 to 12 hours, depending on the severity and type of infection. Max 6 g/day.
Elderly
Dose adjustment may be required based on renal function.
Renal_impairment
Dosage must be reduced according to creatinine clearance.
How to Take
For intramuscular (IM) or intravenous (IV) administration. Must be reconstituted with sterile water for injection or appropriate diluent.
Mechanism of Action
Cefazolin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Within minutes of intravenous (IV) administration.
Excretion
Primarily excreted unchanged by the kidneys via glomerular filtration and tubular secretion.
Half life
Approximately 1.8 hours.
Absorption
Rapidly and completely absorbed after intramuscular (IM) administration. High peak plasma concentrations achieved quickly.
Metabolism
Not significantly metabolized in the body.
Side Effects
Contraindications
- Hypersensitivity to cefazolin or other cephalosporins
- History of severe hypersensitivity to penicillin
Drug Interactions
Probenecid
May increase and prolong cefazolin plasma concentrations.
Nephrotoxic drugs (e.g., aminoglycosides)
Increased risk of nephrotoxicity.
Storage
Store below 30°C in a dry place. Protect from light. Reconstituted solution should be used immediately or stored as per manufacturer's guidelines.
Overdose
Management involves supportive care and symptomatic treatment. Hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Use with caution. Consult doctor. Generally considered safe (Category B), but benefits must outweigh risks. Small amounts are excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to cefazolin or other cephalosporins
- History of severe hypersensitivity to penicillin
Drug Interactions
Probenecid
May increase and prolong cefazolin plasma concentrations.
Nephrotoxic drugs (e.g., aminoglycosides)
Increased risk of nephrotoxicity.
Storage
Store below 30°C in a dry place. Protect from light. Reconstituted solution should be used immediately or stored as per manufacturer's guidelines.
Overdose
Management involves supportive care and symptomatic treatment. Hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Use with caution. Consult doctor. Generally considered safe (Category B), but benefits must outweigh risks. Small amounts are excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, consult specific product label for exact duration.
Availability
Hospitals, Pharmacies
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of cefazolin for its approved indications across various patient populations.
Lab Monitoring
- Renal function (especially in prolonged therapy)
- Liver function tests
- Complete blood count
Doctor Notes
- Always check for penicillin allergy before administration due to potential cross-reactivity.
- Adjust dose in renal impairment to prevent accumulation and toxicity.
- Monitor patients for signs of superinfection, especially C. difficile-associated diarrhea.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if you feel better.
- Report any severe or persistent side effects to your doctor immediately.
- Do not share this medicine with others, and do not use it for infections for which it was not prescribed.
Missed Dose Advice
Contact a healthcare professional for advice. Do not double dose to make up for a missed one.
Driving Precautions
Generally no impact on driving ability, but if you experience dizziness or adverse effects, avoid driving.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids unless advised otherwise by your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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