Adults

Not typically used in this suspension form for adults. For children 6 months to 12 years: 8 mg/kg/day once daily or in two divided doses (4 mg/kg every 12 hours) for 7-14 days depending on infection severity. Maximum 400 mg/day.

Elderly

Not applicable for this pediatric formulation. For adult formulations, dosage adjustment may be necessary in elderly patients with significant renal impairment.

Renal_impairment

For children with creatinine clearance <60 mL/min, dosage adjustment is required. Consult physician for specific recommendations.

Onset

Peak plasma concentration reached within 2-6 hours after oral administration.

Excretion

Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. Some excretion occurs via bile/feces.

Half life

Average plasma half-life is 3-4 hours, but can extend up to 9 hours in some cases.

Absorption

Approximately 30-50% orally absorbed. Absorption may be delayed but not significantly decreased by food.

Metabolism

Not extensively metabolized; primarily eliminated as unchanged drug.

Warfarin

May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Monitor INR/PT closely.

Probenecid

Increases cefixime plasma levels by decreasing renal tubular secretion.

Carbamazepine

May increase carbamazepine levels.

Oral contraceptives

May reduce the efficacy of oral contraceptives (though clinically significant interaction is not well established for all cephalosporins, caution is advised).