Cefivic-DS
Generic Name
Cefixime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cefivic ds 200 mg suspension | ৳ 300.00 | N/A |
Description
Overview of the medicine
Cefivic-DS 200 mg Suspension is an oral antibiotic belonging to the third-generation cephalosporin class. It is used to treat a wide range of bacterial infections in children, including respiratory tract infections, urinary tract infections, and ear infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Not typically used in this suspension form for adults. For children 6 months to 12 years: 8 mg/kg/day once daily or in two divided doses (4 mg/kg every 12 hours) for 7-14 days depending on infection severity. Maximum 400 mg/day.
Elderly
Not applicable for this pediatric formulation. For adult formulations, dosage adjustment may be necessary in elderly patients with significant renal impairment.
Renal_impairment
For children with creatinine clearance <60 mL/min, dosage adjustment is required. Consult physician for specific recommendations.
How to Take
Shake the bottle well before each use. Administer orally with a measuring spoon or oral syringe. Can be taken with or without food. Complete the full course of treatment as prescribed, even if symptoms improve.
Mechanism of Action
Cefixime, a bactericidal antibiotic, works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor.
Pharmacokinetics
Onset
Peak plasma concentration reached within 2-6 hours after oral administration.
Excretion
Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. Some excretion occurs via bile/feces.
Half life
Average plasma half-life is 3-4 hours, but can extend up to 9 hours in some cases.
Absorption
Approximately 30-50% orally absorbed. Absorption may be delayed but not significantly decreased by food.
Metabolism
Not extensively metabolized; primarily eliminated as unchanged drug.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics
- Hypersensitivity to penicillin (risk of cross-reactivity)
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Monitor INR/PT closely.
Probenecid
Increases cefixime plasma levels by decreasing renal tubular secretion.
Carbamazepine
May increase carbamazepine levels.
Oral contraceptives
May reduce the efficacy of oral contraceptives (though clinically significant interaction is not well established for all cephalosporins, caution is advised).
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C). Do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Excreted in small amounts in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics
- Hypersensitivity to penicillin (risk of cross-reactivity)
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Monitor INR/PT closely.
Probenecid
Increases cefixime plasma levels by decreasing renal tubular secretion.
Carbamazepine
May increase carbamazepine levels.
Oral contraceptives
May reduce the efficacy of oral contraceptives (though clinically significant interaction is not well established for all cephalosporins, caution is advised).
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C). Do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Excreted in small amounts in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted powder: 2-3 years. Reconstituted suspension: 7-14 days when refrigerated.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by drug regulatory authorities globally (e.g., FDA, DGDA)
Patent Status
Generic available (Patent expired for Cefixime)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established cefixime's efficacy and safety for various bacterial infections, particularly in pediatric and adult populations. Ongoing surveillance continues to monitor resistance patterns.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with pre-existing renal impairment)
- Complete blood count (CBC) for prolonged therapy
- Liver function tests (rarely needed, but in case of suspected hepatotoxicity)
Doctor Notes
- Cefixime is generally well-tolerated. Counsel patients on the importance of completing the full course to prevent resistance.
- Be mindful of potential cross-reactivity in penicillin-allergic patients.
- Adjust dosage in renal impairment.
Patient Guidelines
- Complete the entire course of medication as prescribed, even if you feel better.
- Do not save medication for future infections.
- Shake the suspension well before each use.
- Use the provided measuring device for accurate dosing.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, if side effects like dizziness or headache occur, avoid such activities until symptoms resolve.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Practice good hygiene to prevent spread of infection.
- Avoid self-medication and always consult a doctor before taking antibiotics.
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International brand names for this medicine. Click a brand to search for detailed information.