Ceforan
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ceforan 100 mg tablet | ৳ 17.05 | ৳ 119.35 |
Description
Overview of the medicine
Ceforan 100 mg tablet contains Cefixime, a third-generation cephalosporin antibiotic used to treat various bacterial infections including those of the respiratory tract, urinary tract, and uncomplicated gonorrhea.
Uses & Indications
Dosage
Adults
Adults and children over 12 years or weighing more than 50 kg: 200-400 mg daily, given as a single dose or in two divided doses. For uncomplicated gonorrhea, a single 400 mg dose.
Elderly
No dosage adjustment needed unless severe renal impairment is present.
Renal_impairment
Creatinine clearance 21-60 mL/min: 75% of standard dose. Creatinine clearance <20 mL/min: 50% of standard dose.
How to Take
Ceforan 100 mg tablet can be taken orally with or without food. To minimize gastric upset, it can be taken with food. The tablet should be swallowed whole with water.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby interfering with the peptidoglycan synthesis that is crucial for maintaining the bacterial cell wall integrity. This leads to cell lysis and bacterial death.
Pharmacokinetics
Onset
Clinical improvement often seen within 24-48 hours.
Excretion
Primarily excreted unchanged in urine (about 50%) and partially through bile.
Half life
3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food slightly delays absorption but does not significantly affect the extent of absorption.
Metabolism
Minimal metabolism in the liver.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or other cephalosporin antibiotics
- Known hypersensitivity to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May increase prothrombin time (PT) and International Normalized Ratio (INR), increasing bleeding risk. Close monitoring of PT/INR is recommended.
Probenecid
Increases cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
Increased carbamazepine levels have been reported with concomitant cefixime administration.
Oral Contraceptives
May reduce efficacy of oral contraceptives (use additional birth control methods).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy: Category B. Studies in animals have shown no evidence of harm to the fetus. Use only if clearly needed. Lactation: Excreted in very small amounts in breast milk. Use with caution during breastfeeding.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or other cephalosporin antibiotics
- Known hypersensitivity to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May increase prothrombin time (PT) and International Normalized Ratio (INR), increasing bleeding risk. Close monitoring of PT/INR is recommended.
Probenecid
Increases cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
Increased carbamazepine levels have been reported with concomitant cefixime administration.
Oral Contraceptives
May reduce efficacy of oral contraceptives (use additional birth control methods).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy: Category B. Studies in animals have shown no evidence of harm to the fetus. Use only if clearly needed. Lactation: Excreted in very small amounts in breast milk. Use with caution during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture, depending on storage conditions.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established cefixime's efficacy and safety for various bacterial infections since its initial approval. Ongoing post-marketing surveillance continues to monitor its long-term profile.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) in patients with pre-existing renal impairment
- Complete blood count (CBC) during prolonged therapy
- PT/INR if co-administered with anticoagulants like warfarin
Doctor Notes
- Advise patients to complete the full course of treatment.
- Counsel on potential C. difficile risk.
- Check for penicillin allergy history before prescribing.
Patient Guidelines
- Take the full course of medication even if symptoms improve to prevent antibiotic resistance.
- Do not share this medication with others.
- Inform your doctor about any allergies or other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cefixime may cause dizziness in some patients. Patients should be advised to exercise caution when driving or operating machinery until they know how Cefixime affects them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol during treatment as it may worsen side effects.
- Get adequate rest to support recovery.
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Global Brand Names
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