Cefotil Plus
Generic Name
Cefuroxime Axetil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cefotil plus 125 mg suspension | ৳ 285.00 | N/A |
Description
Overview of the medicine
Cefotil Plus 125 mg Suspension is an antibiotic used to treat a wide range of bacterial infections. It belongs to the cephalosporin class of antibiotics and works by stopping the growth of bacteria. It is commonly prescribed for respiratory tract infections, urinary tract infections, skin and soft tissue infections, and otitis media, especially in children.
Uses & Indications
Dosage
Adults
This 125 mg suspension is typically not used for adults. Adult dosage usually requires higher strengths (e.g., 250 mg or 500 mg tablets). For children 3 months to 12 years: For most infections, 125 mg twice daily or 10 mg/kg twice daily (max 250 mg twice daily). For otitis media or more severe infections: 250 mg twice daily or 15 mg/kg twice daily (max 500 mg twice daily).
Elderly
Dosage adjustment not generally required in elderly patients unless there is significant renal impairment.
Renal_impairment
Dosage should be adjusted based on creatinine clearance (e.g., for CrCl 10-29 mL/min, administer standard dose every 24 hours; for CrCl <10 mL/min, administer standard dose every 48 hours).
How to Take
Administer orally. Shake the suspension well before each use. It is recommended to take Cefuroxime Axetil with food to enhance absorption and minimize gastrointestinal upset.
Mechanism of Action
Cefuroxime Axetil is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This binding prevents the cross-linking of peptidoglycan chains, leading to the disruption of the bacterial cell wall and eventual cell lysis.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved approximately 2-3 hours after oral administration.
Excretion
Primarily excreted unchanged by the kidneys, via glomerular filtration and tubular secretion.
Half life
Approximately 1.2-1.6 hours.
Absorption
Well absorbed from the gastrointestinal tract, especially when taken with food. Bioavailability is increased in the presence of food.
Metabolism
Rapidly hydrolyzed by esterases in the intestinal mucosa and blood to release active cefuroxime. It is not significantly metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, any other cephalosporin antibiotic, or any component of the formulation.
- History of severe hypersensitivity (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agents (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant administration with probenecid increases the area under the serum concentration versus time curve by 50%.
Oral Contraceptives
Cefuroxime Axetil may affect gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives.
Antacids/H2 blockers/PPIs
Drugs that reduce gastric acidity may reduce the bioavailability of cefuroxime axetil and should be used with caution.
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C) and discard after 10 days. Do not freeze.
Overdose
Overdose of cephalosporins can lead to cerebral irritation, convulsions, or other neurological sequelae. Treatment is supportive. Hemodialysis and peritoneal dialysis can remove cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. Cefuroxime is excreted in breast milk in small amounts. Use during pregnancy and lactation should be done with caution and only if clearly needed after consulting a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unreconstituted powder). 10 days after reconstitution when stored in a refrigerator.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies globally
Patent Status
Generic available, patent expired for Cefuroxime Axetil
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of cefuroxime axetil for various bacterial infections in both adult and pediatric populations.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with pre-existing renal impairment)
- Complete blood count (CBC) (for prolonged therapy)
- Liver function tests (if signs of hepatic dysfunction occur)
Doctor Notes
- Educate patients/parents on the importance of completing the full course.
- Advise patients to take with food for optimal absorption.
- Be aware of potential cross-reactivity in patients with penicillin allergy, especially severe reactions.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve, to prevent recurrence and resistance.
- Take with food to improve absorption and reduce gastrointestinal upset.
- Shake the suspension well before each use.
- Store the reconstituted suspension in the refrigerator and discard any unused portion after 10 days.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
- Avoid self-medication and always consult a doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.