Centamol
Generic Name
Paracetamol 120 mg/5ml Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| centamol 120 mg suspension | ৳ 35.00 | N/A |
Description
Overview of the medicine
Paracetamol is a widely used analgesic and antipyretic. It is used to relieve pain and reduce fever in infants and young children.
Uses & Indications
Dosage
Adults
Not typically used for adults in this strength; adult doses are generally higher (e.g., 500mg or 1g tablets).
Elderly
No specific adjustment needed for elderly unless hepatic or renal impairment is present.
Renal_impairment
Use with caution; dose reduction may be necessary in severe renal impairment (e.g., CrCl < 10 ml/min).
Hepatic_impairment
Use with caution; dose reduction or avoidance may be necessary in severe hepatic impairment.
Pediatric_1_5_years
120-250 mg (5-10 ml) 2-4 times daily
Pediatric_2_3_months
60 mg (2.5 ml) 2-4 times daily (only on doctor's advice)
Pediatric_4_11_months
120 mg (5 ml) 2-4 times daily
How to Take
Orally. Shake the bottle well before use. Administer with a measuring spoon or oral syringe.
Mechanism of Action
Paracetamol is thought to act primarily by inhibiting prostaglandin synthesis in the central nervous system (CNS), leading to analgesic and antipyretic effects.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates, with less than 5% excreted as unchanged drug.
Half life
1-4 hours
Absorption
Readily absorbed from the gastrointestinal tract, peak plasma concentrations typically occur within 30-60 minutes.
Metabolism
Primarily hepatic metabolism via conjugation with glucuronic acid and sulfate. A small amount is metabolized by cytochrome P450 to N-acetyl-p-benzoquinone imine (NAPQI), which is then detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment
Drug Interactions
Alcohol
Increased risk of hepatotoxicity, especially with chronic excessive use.
Warfarin
Increased anticoagulant effect with prolonged high doses of paracetamol.
Carbamazepine, Phenytoin
Increased risk of hepatotoxicity due to enzyme induction.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Hepatotoxicity is the most serious consequence of paracetamol overdose. Symptoms include nausea, vomiting, abdominal pain, and liver damage. Treatment involves gastric lavage, activated charcoal, and N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use in pregnancy and lactation when used at recommended doses, but always consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment
Drug Interactions
Alcohol
Increased risk of hepatotoxicity, especially with chronic excessive use.
Warfarin
Increased anticoagulant effect with prolonged high doses of paracetamol.
Carbamazepine, Phenytoin
Increased risk of hepatotoxicity due to enzyme induction.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Hepatotoxicity is the most serious consequence of paracetamol overdose. Symptoms include nausea, vomiting, abdominal pain, and liver damage. Treatment involves gastric lavage, activated charcoal, and N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use in pregnancy and lactation when used at recommended doses, but always consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Paracetamol has been extensively studied for decades; numerous clinical trials have established its efficacy and safety for pain and fever, particularly in pediatric populations.
Lab Monitoring
- Liver function tests (in cases of overdose or prolonged high-dose therapy)
- Renal function tests (in patients with pre-existing renal impairment)
Doctor Notes
- Emphasize correct dosing for pediatric patients based on weight or age, ensuring parents use the provided measuring device accurately.
- Advise parents on the signs of paracetamol overdose and when to seek immediate emergency care.
- Caution against co-administration with other paracetamol-containing products to avoid accidental overdose.
- Educate on the maximum daily dose and the importance of not exceeding it.
Patient Guidelines
- Do not exceed the recommended dose.
- Do not take with other paracetamol-containing products.
- Consult a doctor if symptoms persist for more than 3 days for fever or 5 days for pain.
- Ensure accurate measurement of dose for children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally considered safe, as it does not typically cause drowsiness or affect concentration.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Get adequate rest to aid recovery.
- Avoid alcohol consumption while taking paracetamol.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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