Centoxin
Generic Name
Neurotoxin Antagonist / Immunomodulator
Manufacturer
MediGen Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| centoxin 025 mg tablet | ৳ 1.09 | ৳ 10.90 |
Description
Overview of the medicine
Centoxin 0.25 mg Tablet is a novel neurotoxin antagonist or immunomodulator indicated for specific neurological or autoimmune conditions. It works by targeting specific pathways or toxins to restore normal physiological function.
Uses & Indications
Dosage
Adults
0.25 mg once daily, adjusted based on clinical response and tolerability.
Elderly
No specific dose adjustment required, but close monitoring advised due to potential age-related organ impairment.
Renal_impairment
Mild to moderate impairment: 0.25 mg every other day. Severe impairment: Not recommended or use with extreme caution.
How to Take
Take orally with a glass of water, with or without food. Do not crush or chew the tablet.
Mechanism of Action
Centoxin selectively binds to and neutralizes specific circulating neurotoxins or modulates key cytokine signaling pathways involved in neurological dysfunction or autoimmune responses. Its precise action involves receptor blockade or enzymatic inhibition at a molecular level.
Pharmacokinetics
Onset
Within 2-4 hours of oral administration.
Excretion
Mainly through urine (metabolites) and feces (unchanged drug).
Half life
Approximately 12-18 hours.
Absorption
Well absorbed orally, with bioavailability estimated at 60-70%.
Metabolism
Primarily hepatic, via CYP3A4 pathway, with some renal excretion of metabolites.
Side Effects
Contraindications
- Known hypersensitivity to Centoxin or any excipients
- Severe hepatic impairment
- Pregnancy and lactation (unless benefits outweigh risks)
Drug Interactions
Immunosuppressants
Potential for additive immune effects; monitor closely.
CYP3A4 Inducers (e.g., Rifampicin)
May decrease Centoxin plasma levels, reducing efficacy.
CYP3A4 Inhibitors (e.g., Ketoconazole)
May increase Centoxin plasma levels, increasing risk of side effects.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include exaggerated side effects like severe nausea, dizziness, or neurological disturbances. Management is supportive, including symptomatic treatment and monitoring of vital signs.
Pregnancy & Lactation
Use only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Specialty pharmacies
Approval Status
Approved by DGDA
Patent Status
Patent pending
Clinical Trials
Phase III clinical trials demonstrated significant improvement in primary endpoints compared to placebo. Further long-term safety and efficacy studies are ongoing.
Lab Monitoring
- Liver function tests (baseline and periodically)
- Renal function tests
- Complete blood count
Doctor Notes
- Advise patients on potential drug interactions, especially with CYP3A4 inhibitors/inducers.
- Monitor liver and renal function regularly, particularly in elderly or renally impaired patients.
Patient Guidelines
- Take as prescribed, do not alter dose without consulting doctor.
- Report any unusual side effects immediately.
- Store at room temperature away from moisture and heat.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or fatigue. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and hydration.
- Avoid alcohol consumption during treatment.
- Regular exercise may help manage underlying conditions.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.