Cephracap-DS
Generic Name
Cefixime 250 mg Suspension
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cephracap ds 250 mg suspension | ৳ 120.00 | N/A |
Description
Overview of the medicine
Cephracap-DS 250 mg Suspension contains Cefixime, a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It is effective against many Gram-positive and Gram-negative bacteria.
Uses & Indications
Dosage
Adults
The usual adult dose is 400 mg daily, given as a single dose or in two divided doses of 200 mg every 12 hours. For 250 mg suspension, dose adjustment based on the product formulation or physician's discretion.
Elderly
No dosage adjustment is generally required unless renal function is significantly impaired.
Renal_impairment
For patients with creatinine clearance less than 60 mL/min, the dose should be reduced. For CrCl 21-60 mL/min, 200 mg daily. For CrCl <20 mL/min, 100 mg daily.
How to Take
Administer orally with or without food. Shake the suspension well before each use. Use a calibrated measuring device to ensure accurate dosing.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Within 1 hour (peak plasma concentrations).
Excretion
Approximately 50% excreted unchanged in urine within 24 hours. Renal impairment prolongs half-life.
Half life
3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food slightly delays absorption but does not significantly affect the extent of absorption.
Metabolism
Not extensively metabolized; primarily eliminated as unchanged drug.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to any penicillin.
Drug Interactions
Warfarin
May increase prothrombin time (INR) and risk of bleeding. Close monitoring of INR is recommended.
Nifedipine
May increase cefixime Cmax and AUC.
Carbamazepine
Increased plasma levels of carbamazepine have been reported when co-administered with cefixime.
Storage
Store dry powder below 30°C in a dry place, away from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard any unused portion after the specified period.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Cefixime crosses the placenta but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Excreted in low concentrations into breast milk; caution advised during lactation.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to any penicillin.
Drug Interactions
Warfarin
May increase prothrombin time (INR) and risk of bleeding. Close monitoring of INR is recommended.
Nifedipine
May increase cefixime Cmax and AUC.
Carbamazepine
Increased plasma levels of carbamazepine have been reported when co-administered with cefixime.
Storage
Store dry powder below 30°C in a dry place, away from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard any unused portion after the specified period.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Cefixime crosses the placenta but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Excreted in low concentrations into breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months for unreconstituted dry powder. Reconstituted suspension is stable for 7-14 days when stored as directed.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections, confirming its role as a broad-spectrum oral antibiotic.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with pre-existing renal impairment or during prolonged high-dose therapy.
- Complete blood count (CBC) during prolonged therapy.
Doctor Notes
- Prescribe based on bacterial susceptibility tests where possible.
- Educate patients on the importance of completing the full course of therapy.
- Monitor for signs of Clostridium difficile-associated diarrhea (CDAD) following antibiotic use.
Patient Guidelines
- Complete the entire course of medication as prescribed, even if symptoms improve.
- Do not save medication for future infections or share it with others.
- Shake the suspension well before each use.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime is not known to impair the ability to drive or operate machinery. However, if dizziness occurs, exercise caution.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Drink plenty of fluids unless otherwise advised by your doctor.
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Global Brand Names
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