Adults

The usual adult dose is 400 mg daily, given as a single dose or in two divided doses of 200 mg every 12 hours. For 250 mg suspension, dose adjustment based on the product formulation or physician's discretion.

Elderly

No dosage adjustment is generally required unless renal function is significantly impaired.

Renal_impairment

For patients with creatinine clearance less than 60 mL/min, the dose should be reduced. For CrCl 21-60 mL/min, 200 mg daily. For CrCl <20 mL/min, 100 mg daily.

Onset

Within 1 hour (peak plasma concentrations).

Excretion

Approximately 50% excreted unchanged in urine within 24 hours. Renal impairment prolongs half-life.

Half life

3-4 hours.

Absorption

Approximately 40-50% orally absorbed. Food slightly delays absorption but does not significantly affect the extent of absorption.

Metabolism

Not extensively metabolized; primarily eliminated as unchanged drug.

Warfarin

May increase prothrombin time (INR) and risk of bleeding. Close monitoring of INR is recommended.

Nifedipine

May increase cefixime Cmax and AUC.

Carbamazepine

Increased plasma levels of carbamazepine have been reported when co-administered with cefixime.