Cerzin
Generic Name
Cetirizine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cerzin 10 mg tablet | ৳ 2.50 | N/A |
Description
Overview of the medicine
Cerzin is an antihistamine used to relieve symptoms of allergies such as runny nose, sneezing, itchy or watery eyes, and itching of the nose or throat. It is also used to treat hives.
Uses & Indications
Dosage
Adults
10 mg once daily, preferably in the evening.
Elderly
Initial dose 5 mg once daily, adjust based on renal function.
Renal_impairment
Moderate renal impairment (CrCl 31-50 ml/min): 5 mg once daily. Severe renal impairment (CrCl < 30 ml/min): 5 mg every other day.
How to Take
May be taken with or without food. For oral use.
Mechanism of Action
Cetirizine is a potent and selective antagonist of peripheral H1-receptors. It inhibits the early phase of the allergic reaction and also reduces the migration of inflammatory cells and the release of mediators involved in the late phase allergic reaction.
Pharmacokinetics
Onset
Within 20-60 minutes.
Excretion
Primarily excreted unchanged in the urine.
Half life
Approximately 8-10 hours in adults, longer in elderly and renal impaired patients.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 1 hour.
Metabolism
Only a small portion is metabolized in the liver to an inactive metabolite.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives.
- Severe renal impairment (CrCl < 10 ml/min).
Drug Interactions
Theophylline
May decrease cetirizine clearance.
CNS depressants (alcohol, sedatives)
Increased drowsiness.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, tremor, headache, confusion, malaise, mydriasis, pruritus, agitation, and urinary retention. Treatment is symptomatic and supportive; no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted into breast milk, not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety for allergic conditions.
Lab Monitoring
- No specific routine lab monitoring is generally required. Renal function may be monitored in patients with kidney impairment.
Doctor Notes
- Advise patients on potential sedation and interaction with alcohol.
- Consider dose adjustment in elderly and renal impaired patients.
Patient Guidelines
- Take as directed by your doctor.
- Avoid driving or operating heavy machinery if drowsiness occurs.
- Do not consume alcohol while taking this medicine.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness; avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Identify and avoid allergy triggers.
- Maintain a clean environment to reduce exposure to allergens.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.