Chlormet
Generic Name
Chloramphenicol
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| chlormet 01 05 eye drop | ৳ 70.00 | N/A |
Description
Overview of the medicine
Chloramphenicol is a broad-spectrum antibiotic eye drop used to treat bacterial eye infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
One or two drops into the affected eye(s) every 2-4 hours, reducing frequency as infection improves. Continue for at least 48 hours after symptoms resolve.
Elderly
No specific dose adjustment required.
Renal_impairment
No specific dose adjustment required for topical ophthalmic use.
How to Take
Wash hands thoroughly before use. Tilt head back, pull down lower eyelid to create a pouch. Instill the prescribed number of drops without touching the eye or eyelid with the dropper tip. Close eye gently for a few moments.
Mechanism of Action
Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation.
Pharmacokinetics
Onset
Clinical improvement usually seen within 24-48 hours.
Excretion
Renal excretion of metabolites if systemic absorption.
Half life
Not significant systemically; locally, effect persists for several hours.
Absorption
Limited systemic absorption following topical ophthalmic administration. Local absorption into ocular tissues.
Metabolism
Primarily hepatic metabolism if significant systemic absorption occurs, but minimal for topical use.
Side Effects
Contraindications
- Hypersensitivity to chloramphenicol or any excipients.
- Patients with a history of bone marrow depression, including aplastic anemia.
Drug Interactions
Bone marrow depressants
Increased risk of bone marrow suppression.
Other ophthalmic preparations
Administer at least 5 minutes apart.
Storage
Store below 25°C. Do not freeze. Keep out of reach of children.
Overdose
Overdose with topical ophthalmic chloramphenicol is unlikely to cause systemic toxicity due to limited absorption. If accidental ingestion occurs or excessive topical use, supportive measures may be necessary.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and the potential benefits outweigh the potential risks. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to chloramphenicol or any excipients.
- Patients with a history of bone marrow depression, including aplastic anemia.
Drug Interactions
Bone marrow depressants
Increased risk of bone marrow suppression.
Other ophthalmic preparations
Administer at least 5 minutes apart.
Storage
Store below 25°C. Do not freeze. Keep out of reach of children.
Overdose
Overdose with topical ophthalmic chloramphenicol is unlikely to cause systemic toxicity due to limited absorption. If accidental ingestion occurs or excessive topical use, supportive measures may be necessary.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and the potential benefits outweigh the potential risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 years unopened; discard 28 days after opening.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of chloramphenicol for bacterial eye infections, dating back decades.
Lab Monitoring
- Not typically required for short-term topical ophthalmic use.
Doctor Notes
- Counsel patients on proper administration technique to avoid contamination.
- Monitor for signs of superinfection or allergic reactions.
Patient Guidelines
- Do not share eye drops with others.
- Remove contact lenses before application and wait at least 15 minutes before reinserting.
- Complete the full course of treatment, even if symptoms improve.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
May cause temporary blurred vision. Avoid driving or operating machinery until vision clears.
Lifestyle Advice
- Avoid touching the eye with unwashed hands.
- Maintain good personal hygiene to prevent spread of infection.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.