Cifirate
Generic Name
Cifirate
Manufacturer
MediHealth Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cifirate 100 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Cifirate 100 mg Tablet is a non-opioid analgesic and anti-inflammatory drug used for the management of mild to moderate pain and inflammation associated with various conditions.
Uses & Indications
Dosage
Adults
100 mg once or twice daily, as directed by physician. Maximum 200 mg/day.
Elderly
Initiate with lower dose (e.g., 50 mg daily) and titrate carefully based on response and tolerability.
Renal_impairment
Dose adjustment required for severe renal impairment; consider 50 mg daily or alternate day dosing.
How to Take
Administer orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water; do not crush or chew.
Mechanism of Action
Cifirate selectively inhibits specific pain mediators and inflammatory pathways, possibly involving modulation of specific cyclooxygenase (COX) isoforms or novel pain receptors, leading to reduced prostaglandin synthesis and inflammatory response.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Mainly excreted in urine (60-70%) and feces (30-40%) as metabolites.
Half life
Approximately 4-6 hours
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes (e.g., CYP3A4, CYP2C9).
Side Effects
Contraindications
- Hypersensitivity to Cifirate or its excipients
- Severe renal or hepatic impairment
- Active gastrointestinal bleeding or peptic ulcer
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding due to enhanced anticoagulant effect.
Diuretics
May reduce the natriuretic effect of loop and thiazide diuretics.
ACE Inhibitors
May attenuate the antihypertensive effect.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, lethargy, dizziness, and headache. In severe cases, gastrointestinal bleeding, acute renal failure, and respiratory depression may occur. Treatment is symptomatic and supportive; gastric lavage, activated charcoal, and monitoring of vital signs may be necessary.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm. Use with caution during the first two trimesters and lactation only if clearly needed and the potential benefits outweigh the risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent protected
Clinical Trials
Phase III clinical trials demonstrated efficacy in chronic pain and osteoarthritis with favorable safety profile. Ongoing post-market surveillance studies.
Lab Monitoring
- Liver function tests (LFTs)
- Renal function tests (e.g., serum creatinine, BUN)
- Complete blood count (CBC)
Doctor Notes
- Caution in patients with pre-existing cardiovascular disease or risk factors.
- Monitor renal and hepatic function during long-term therapy.
- Educate patients on potential GI and cardiovascular risks.
Patient Guidelines
- Take Cifirate 100 mg Tablet exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any unusual symptoms or side effects immediately.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Cifirate may cause dizziness or drowsiness in some individuals. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Engage in regular light exercise if appropriate for your condition.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.