Cinaron Plus
Generic Name
Cinnarizine + Dimenhydrinate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cinaron plus 20 mg tablet | ৳ 2.00 | ৳ 28.00 |
Description
Overview of the medicine
Cinaron Plus 20 mg Tablet is a combination medicine containing Cinnarizine and Dimenhydrinate. It is primarily used to treat symptoms associated with vertigo, such as dizziness, nausea, vomiting, and ringing in the ears (tinnitus). Cinnarizine helps in controlling blood flow to the inner ear, while Dimenhydrinate has antihistaminic and antiemetic properties to reduce nausea and vomiting.
Uses & Indications
Dosage
Adults
1 tablet two to three times daily, preferably with meals. Maximum 3 tablets per day.
Elderly
Same as adults, but caution is advised. Dosage adjustment may be needed based on renal/hepatic function.
Renal_impairment
Use with caution. Dosage reduction may be necessary in severe renal impairment.
How to Take
Oral. Take tablets with sufficient liquid, preferably after meals to minimize gastrointestinal irritation.
Mechanism of Action
Cinnarizine acts as a calcium channel blocker, inhibiting the influx of calcium into vascular smooth muscle cells, particularly in the inner ear, thereby reducing vestibular stimulation. It also has antihistaminic properties. Dimenhydrinate is an H1-receptor antagonist with significant anticholinergic and antiemetic effects. It primarily suppresses vestibular stimulation and blocks chemoreceptor trigger zone (CTZ) activity, reducing nausea and vomiting.
Pharmacokinetics
Onset
Onset of action within 30-60 minutes.
Excretion
Mainly excreted via urine and feces.
Half life
Cinnarizine: 4 hours. Dimenhydrinate: 4-6 hours.
Absorption
Cinnarizine: Well absorbed from the GI tract. Dimenhydrinate: Readily absorbed.
Metabolism
Both primarily metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to cinnarizine or dimenhydrinate or any excipients
- Acute asthma attacks
- Narrow-angle glaucoma
- Prostatic hypertrophy
- Children under 18 years (as per some guidelines for this combination)
Drug Interactions
MAO Inhibitors
May prolong and intensify the anticholinergic effects of dimenhydrinate.
CNS Depressants (e.g., alcohol, sedatives, hypnotics)
Increased sedative effects.
Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
Increased anticholinergic side effects (e.g., dry mouth, blurred vision, urinary retention).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, ataxia, anticholinergic effects (dry mouth, blurred vision, urinary retention), and CNS excitation (especially in children). Treatment is symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Not recommended during pregnancy and lactation unless the potential benefits outweigh the risks. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to cinnarizine or dimenhydrinate or any excipients
- Acute asthma attacks
- Narrow-angle glaucoma
- Prostatic hypertrophy
- Children under 18 years (as per some guidelines for this combination)
Drug Interactions
MAO Inhibitors
May prolong and intensify the anticholinergic effects of dimenhydrinate.
CNS Depressants (e.g., alcohol, sedatives, hypnotics)
Increased sedative effects.
Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
Increased anticholinergic side effects (e.g., dry mouth, blurred vision, urinary retention).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, ataxia, anticholinergic effects (dry mouth, blurred vision, urinary retention), and CNS excitation (especially in children). Treatment is symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Not recommended during pregnancy and lactation unless the potential benefits outweigh the risks. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved by local regulatory authorities
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of cinnarizine and dimenhydrinate combination in treating vertigo and associated symptoms. Specific trials for Cinaron Plus may vary by manufacturer.
Lab Monitoring
- Not typically required for routine use.
Doctor Notes
- Advise patients about potential drowsiness and to avoid activities requiring mental alertness.
- Caution in elderly patients and those with prostatic hypertrophy or glaucoma due to anticholinergic effects.
- Ensure patients understand the importance of taking with food to reduce GI upset.
Patient Guidelines
- Do not drive or operate heavy machinery if you experience drowsiness.
- Avoid alcohol consumption during treatment.
- Take the tablet with meals to reduce stomach upset.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause drowsiness. Avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Avoid sudden movements that might trigger vertigo.
- Stay hydrated and get adequate rest.
- Avoid excessive caffeine or stimulants.
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Global Brand Names
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